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Latest Application Notes

Application Note

Target-Class Selectivity Profiling for Deubiquitinase (DUB) Inhibitors

Download this app note to discover a solution that provides accurate quantification with multiplexed stable isotope reagents, unprecedented coverage of cellular DUB enzymes and evidence that hits in a high-throughput biochemical screen are indeed selective for intended targets.
Application Note

Microbubbles Offer a Versatile, Flexible Platform for Targeted Capture of Diverse Analytes

Download this app note to discover a solution that can be used with any biotinylated affinity molecule, enables floatation-based separation of diverse targets as well as provides workflows that are exceptionally gentle on delicate analytes.
Application Note

Improve Your XL-MS Results

Proteins typically fold into well-defined tertiary structures and interact with other proteins to form homo- and hetero-oligomers to accomplish their physiological functions. These functions have implications on health and disease, but are also relevant for biotechnology applications.
Application Note

Revolutionizing Drug Discovery in Hematological Oncology

The approach to treating hematological malignancies is rapidly evolving as we discover the underlying mechanisms of disease and identify new immune pathways within the patient’s body to harness.
Application Note

Reliable and High-Throughput Cell Viability Assays

The determination of cell viability in any cell culture is a crucial analytical measurement for any study. One of the most common ways to measure cell viability is via the determination of the cell membrane’s integrity.
Application Note

Transforming Drug Discovery Through Precision Research

The high resolution and scale that single cell analysis provides is revolutionizing drug discovery and development by introducing comparative, longitudinal and causal information that transforms our ability to understand biology and disease.
Application Note

Imaging Organoids With Light-Sheet Fluorescence Microscopy

Studying tissue and organ biology is challenging, particularly in mammals, given sample accessibility and ethical concerns. However, the use of organoids alleviates these challenges, supporting researchers in exploring questions that previously could not have been investigated without them.
Application Note

Accurate Quantification of Interferon Gamma Across Immunoassay Platforms

Download this app note to discover immunoassay platforms that are consistent for your cell therapy and immunology development needs.
Application Note

Organoids for Disease Modeling and In Vitro Drug Screening

While the complexity of organoids remains challenging, technological advances are enabling organoids to be developed and monitored in an automated fashion, so that they can be exploited in high-throughput drug screening assays.
Application Note

3D Co-Culture Spheroids With Human Liver Cells

With the advances in 3D culture, liver spheroids made from primary human hepatocytes have been demonstrated to be a useful novel tool for in vitro hepatotoxicity studies.
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