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Latest App Notes & Case Studies

App Note / Case Study

Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
App Note / Case Study

Recording of ICRAC in RBL-1 Cells on the PatchXpress 7000A Automated Patch Clamp System

Calcium release-activated calcium (CRAC) channels play an important role in intracellular Ca2+ homeostasis. Like other store-operated calcium channels, currents through the CRAC channel (ICRAC) are activated by depletion of calcium in the endoplasmic reticulum (ER) and serve the purpose of slowly replenishing the ER with Ca2+.
App Note / Case Study

BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay

The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
App Note / Case Study

DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
App Note / Case Study

Growth of Campylobacter using BMG LABTECH’s FLUOstar Omega equipped with ACU

Campylobacter are Gram negative microaerophilic organisms which are a common commensal of mammals and birds and are one of the most frequently isolated causative agents of human bacterial enteritis worldwide. Infection in humans is frequently associated with the consumption of under cooked poultry and is generally self limiting though it can in a small number of cases result in severe complications such as Guillain-Barre syndrome.
App Note / Case Study

Miniaturised Platelet Aggregation Assays using the NOVOstar Microplate Reader

Platelets are small, anucleate blood cells derived from their precursor cells, megakaryocytes that are vital for haemostasis. Following blood vessel injury, subendothelial collagens are exposed to which platelets adhere. The detailed characterisation of platelet function and underlying regulatory mechanisms is important for the development of new strategies to selectively reduce platelet reactivity and prevent thrombosis.
App Note / Case Study

mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA

Glutathione is one of the major antioxidants/redox molecules in most aerobic cells, playing an important role in cell metabolism, differentiation, proliferation, and apoptosis. The reduced form of glutathione (GSH) is required for the detoxification of drugs and reactive compounds of both endogenous and exogenous origin.
App Note / Case Study

Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability

The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.
App Note / Case Study

The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH

ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
App Note / Case Study

An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega

G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
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