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Latest App Notes & Case Studies

App Note / Case Study

A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition

Pgp expression has been linked to the effl ux of chemotherapeutic
drugs in human cancers leading to multidrug resistance. Pgp
activity can also result in low oral absorption and poor brain
penetration. Interaction of drugs with the Pgp may also cause
an increase in toxicity of co-administered compounds.
App Note / Case Study

Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay

Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
App Note / Case Study

LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader

LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
App Note / Case Study

Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays

When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
App Note / Case Study

Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex

The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
App Note / Case Study

Turbidometric Growth Curve Measurements and Liquid Evaporation Studies with a Microplate Photometer

The turbidity of a liquid sample is traditionally measured either with a nephelometer or a photometer. The measure of turbidity (also called optical density, OD) refers to the scattering of light from the particles of the measured sample. When measuring turbidity of a bacterial culture, the amount of scattered light is directly proportional to the number of bacterial cells in the sample.
App Note / Case Study

High Sensitivity ELISA Assays for the Detection of Melamine Residuals in Milk

Melamine is an industrial chemical most commonly used as a fire retardant in dry powder extinguishers due to its release of nitrogen gas when burned or charred. Melamine has been used illegally by adding it to food products in order to increase the apparent protein content.
App Note / Case Study

Facilitating Biofilms Assays with Thermo Scientific Multidrop® Combi Dispenser

In recent years, the automation of cell (including bacteria)-based screening assays has consistently shown to provide reduced times and considerable labor saving, while maintaining or increasing assay quality during screening campaigns.
App Note / Case Study

Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes

The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
App Note / Case Study

Dispense Liquids Containing Proteins More Reliably with Reverse Pipetting

This application note demonstrates how the reverse pipetting technique can improve the repeatability of dispensing liquids that contain proteins.
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