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3D Co-Culture Spheroids With Human Liver Cells

More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. While Drug-Induced Liver Injury remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances in 3D culture, liver spheroids made from primary human hepatocytes have been demonstrated to be a useful novel tool for in vitro hepatotoxicity studies.

Download this app note to learn more about:

  • Co-culture liver spheroid formation
  • How to better understand the role of non-parenchymal cells
  • Further optimization of spheroid culture