3D Co-Culture Spheroids With Human Liver Cells
More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. While Drug-Induced Liver Injury remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances in 3D culture, liver spheroids made from primary human hepatocytes have been demonstrated to be a useful novel tool for in vitro hepatotoxicity studies.
Download this app note to learn more about:
- Co-culture liver spheroid formation
- How to better understand the role of non-parenchymal cells
- Further optimization of spheroid culture