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3D Co-Culture Spheroids With Human Liver Cells

3D Co-Culture Spheroids With Human Liver Cells content piece image

More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. While Drug-Induced Liver Injury remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances in 3D culture, liver spheroids made from primary human hepatocytes have been demonstrated to be a useful novel tool for in vitro hepatotoxicity studies.

Download this app note to learn more about:

  • Co-culture liver spheroid formation
  • How to better understand the role of non-parenchymal cells
  • Further optimization of spheroid culture