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Latest App Notes & Case Studies

App Note / Case Study

New Standards for Plasma Proteomics

Identifying novel biomarkers with bottom-up proteomics remains a substantial challenge due to the wide concentration ranges and potentially low abundance of important analytes.
App Note / Case Study

Rapid 4D Analysis of Lipid Nanoparticle Components

Lipid nanoparticles (LNPs) have emerged as effective delivery vehicles for mRNA vaccines and nucleic acid-based drugs. Hence, the analysis of their composition, stability, and biological interactions is essential in drug development and delivery.
Medical Components App Note
App Note / Case Study

Achieve Confident Extractable Testing for Medical Device Compliance

Accelerated solvent extraction (ASE) is an effective extractable profiling technique. However, the poor solubility of certain compounds can result in result in reduced recovery rates and can compromise analytical accuracy.
Genotoxic App Note Preview
App Note / Case Study

Confidence in Compliance: Genotoxic Impurity Analysis

Stringent safety requirements associated with the analyses of carcinogenic and mutagenic impurities can present significant challenges. Methods must achieve a high level of sensitivity and selectivity while maintaining sufficient sample throughput.
Protein Expression
App Note / Case Study

The New Gold Standard for Gene Therapy Protein Expression Potency Measurements

A major challenge preventing transformative gene therapies from reaching patients is the lack of fit-for purpose potency assays, which are some of the most important assays in an analytical package but are often the most complex and high-risk.
Successful SPR Assays
App Note / Case Study

Determining Real-Time Kinetics and Affinity

This compendium serves as a user-friendly reference for assay design on both bio-layer interferometry (BLI) and surface plasmon resonance (SPR) systems.
Oligos with Confidence
App Note / Case Study

Characterize Your Oligos With Confidence

Custom oligo synthesis can result in the formation of impurities. Hence, final products must be characterized to ensure they meet quality assurance and control standards.
Precision Oligo Sequencing
App Note / Case Study

A Simplified Method for Precise Oligo Sequencing

LC/MS methods can be used to analyze a wide range of oligo samples. However, ion-pairing reagents can interfere with analyses and present challenges in multi-use systems.
App Note / Case Study

Fast Track Antigen-Specific B- and T-Cell Discovery

This application note demonstrates how Single Cell Immune Profiling and Barcode Enabled Antigen Mapping (BEAM) can be used to profile thousands of hPBMCs from a single donor.

CAR T: A Promising Cell Therapy for Cancer Treatment content piece image
App Note / Case Study

CAR T: A Promising Cell Therapy for Cancer Treatment

CAR-T cell therapy has emerged as one of the most promising novel treatments in the fight against cancer.