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Latest Application Notes

Application Note

Applications Using Human Liver Spheroids

Recently, the advantages of PHH liver spheroids use in liver toxicity tests over the traditional 2D monolayer culture of PHHs has been demonstrated by many scientists.
Application Note

Enhancing the Therapeutic Properties of a Cancer-Targeting Affibody by Soft Mutagenesis

Affibodies are synthetic antigen-binding proteins. They offer many advantages over monoclonal antibodies, including smaller sizes, enhanced thermal stability and rapid refolding capability. These advantages make affibodies an attractive platform for the development of therapeutics, diagnostics and bioimaging technology.
Application Note

Tiling Across Viral Genomes to Investigate Immune Escape

Viruses exploit high-dimensional RNA structures to facilitate viral replication and impede host restriction. Here, a novel next-generation sequencing (NGS)-based screening workflow, called Fate-seq, was used to define and characterize high-dimensional RNA structures.
Application Note

Discover Triple Quadrupole ICP-MS for the Analysis of Trace Elements

Triple quadrupole ICP-MS systems allow for consistent interference removal regardless of the sample matrix and provide a significant improvement for detection limits of challenging analytes.
Application Note

Convenient Customization of Your Cation Exchange Analysis

Therapeutic monoclonal antibodies (mAbs) are highly heterogeneous molecules due to being composed of a large number of variants. When the variants are present in the pharmaceutical protein, it is possible their biological activity could be altered.
Application Note

Confidence in Your Nitrosamine Impurity Analysis

After the discovery of unacceptable levels of nitrosamine contaminations in certain drug products, regulatory agencies around the world have mandated stringent guidelines and analytical testing of all pharmaceuticals, especially chemically synthesized ones.
Application Note

Solutions for Pharmaceutical Impurities

With an ever-increasing consumption of pharmaceutical products by the world population, there are considerable concerns about the unknowns and impurities which are ingested along with these medicinal drugs
Application Note

Solutions for Pharmaceutical Analysis

Pharmaceutical analysis in drug development mainly focuses on methods to identify and quantify potential new drug candidates. It is imperative that effective, robust methods are used to maintain the safety of the product.
Application Note

Enabling Real-Time Release of Final Products in Manufacturing of Biologics

The structural and chemical complexity of biologics, combined with the intricacy of cell-based manufacturing, imposes a huge analytical burden to correctly characterize and quantify both processes (upstream) and products (downstream).
Application Note

Preventing Cell Death

Download this app note to discover a system that can be used for product formulation, diafiltration solutions as well as extraction, rinsing and sanitization steps.
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