Latest Application Notes
Predicting Drug Permeability With a Gut Microphysiological System
Download this app note to discover a gut MPS that has physiologically relevant morphology, reduced barrier integrity and mucus expression. It can be used to predict drug permeability across an intestinal barrier.
Black Pepper Authenticity Workflow
Food fraud is a rapidly growing and evolving business, therefore several analytical methods have recently been developed to address the concern regarding food adulteration.
Convenient and Reliable Analysis of Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) are monoclonal antibodies to which a cytotoxic small molecule drug is chemically linked. The structures of ADCs are more complex than their corresponding antibodies.
Preparation of Buffers and Solutions for Therapeutic Antibody Analysis
Antibodies are subject to instability issues due to chemical and physical instabilities and these effects can change the pharmacokinetics of the antibody. For this reason, produced antibodies must be thoroughly tested before they can be applied for treatment of patients.
CE-MS Solutions Enabling Next-Generation Therapeutics
Download this info kit to discover solutions that can analyze compounds with positive or negative polarity and provide easy-to-use kits for a variety of protein workflows.
A Validated Method for the Rapid Determination of Fifteen Nitrosamines
Nitrosamines are categorized as probable carcinogens by the ICH M7 (R1) guideline. Since June 2018, several drugs have been recalled due to the presence of these impurities, in particular the U.S.
Your Guide to mAb Variants
Antibody-based derivatives have received increased attention as therapeutics in biopharmaceutical development because of their unique capacity to engage multiple molecular targets, engage immune effector cells or even penetrate tissues previously inaccessible to conventional mAbs.
Analysis of Genotoxic Nitrosamines in Losartan
Download this app note to discover a system that demonstrates good chromatographic separation of nitrosamine compounds and provides enhanced sensitivity.
Greater Precision for Transformative Drug Discovery
Target identification and characterization are key challenges in drug discovery and begin with identifying the function of a possible therapeutic target and its role in the disease.
Development of an AlphaLISA Protein-Protein Interaction Assay To Screen for Re-Purposed Drugs as Targeted Disruptors
The threat of global pandemics emphasises the quick identification of the cause of an emerging disease and its route of infection. Once these characteristics are defined, drug repurposing offers to identify previously approved drugs that might be applicable and quickly approvable for the treatment of the new disease.