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Latest Application Notes

Application Note

Predicting Drug Permeability With a Gut Microphysiological System

Download this app note to discover a gut MPS that has physiologically relevant morphology, reduced barrier integrity and mucus expression. It can be used to predict drug permeability across an intestinal barrier.
Application Note

Black Pepper Authenticity Workflow

Food fraud is a rapidly growing and evolving business, therefore several analytical methods have recently been developed to address the concern regarding food adulteration.
Application Note

Convenient and Reliable Analysis of Antibody–Drug Conjugates

Antibody–drug conjugates (ADCs) are monoclonal antibodies to which a cytotoxic small molecule drug is chemically linked. The structures of ADCs are more complex than their corresponding antibodies.
Application Note

Preparation of Buffers and Solutions for Therapeutic Antibody Analysis

Antibodies are subject to instability issues due to chemical and physical instabilities and these effects can change the pharmacokinetics of the antibody. For this reason, produced antibodies must be thoroughly tested before they can be applied for treatment of patients.
Application Note

CE-MS Solutions Enabling Next-Generation Therapeutics

Download this info kit to discover solutions that can analyze compounds with positive or negative polarity and provide easy-to-use kits for a variety of protein workflows.
Application Note

A Validated Method for the Rapid Determination of Fifteen Nitrosamines

Nitrosamines are categorized as probable carcinogens by the ICH M7 (R1) guideline. Since June 2018, several drugs have been recalled due to the presence of these impurities, in particular the U.S.
Application Note

Your Guide to mAb Variants

Antibody-based derivatives have received increased attention as therapeutics in biopharmaceutical development because of their unique capacity to engage multiple molecular targets, engage immune effector cells or even penetrate tissues previously inaccessible to conventional mAbs.
Application Note

Analysis of Genotoxic Nitrosamines in Losartan

Download this app note to discover a system that demonstrates good chromatographic separation of nitrosamine compounds and provides enhanced sensitivity.
Application Note

Greater Precision for Transformative Drug Discovery

Target identification and characterization are key challenges in drug discovery and begin with identifying the function of a possible therapeutic target and its role in the disease.
Application Note

Development of an AlphaLISA Protein-Protein Interaction Assay To Screen for Re-Purposed Drugs as Targeted Disruptors

The threat of global pandemics emphasises the quick identification of the cause of an emerging disease and its route of infection. Once these characteristics are defined, drug repurposing offers to identify previously approved drugs that might be applicable and quickly approvable for the treatment of the new disease.
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