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Latest App Notes & Case Studies

Resolve the Complex Cellular Diversity of Your Samples content piece image
App Note / Case Study

Resolve the Complex Cellular Diversity of Your Samples

Single-cell RNA sequencing produces a substantial amount of complex data that can be a burden if you don’t have time to become an expert in bioinformatics.
Simple and Fast Tracking of Drug–Antibody Ratio Distribution content piece image
App Note / Case Study

Simple and Fast Tracking of Drug–Antibody Ratio Distribution

Antibody drug conjugates (ADCs) are biotherapeutics, composed of small molecule drugs conjugated to an antibody scaffold, that have very complex molecular structures.
Consistency is Key to Further Drug Discovery Research content piece image
App Note / Case Study

Consistency is Key to Further Drug Discovery Research

Energy metabolism plays a central role in a wide variety of cellular and physiological processes. Therefore, a deep understanding of how disruption to energy metabolism impacts cells can help in therapeutic drug discovery and development.
Recombinant Protein Expression Using a Baculovirus–Insect Cell System content piece image
App Note / Case Study

Recombinant Protein Expression Using a Baculovirus–Insect Cell System

Download this app note to discover a method of recombinant protein expression that enables correct protein folding and post translational modification, is suitable for high-density cell culture, and can produce both secreted and intracellular proteins of various species.
Developing Next-Generation <i>In Vitro</i> Phenotypic Assays for Huntington’s Disease content piece image
App Note / Case Study

Developing Next-Generation In Vitro Phenotypic Assays for Huntington’s Disease

There is currently no effective cure or treatment to slow down or stop the progression of Huntington's disease (HD). One reason for this is the lack of accurate and easy-to-use HD models.
RatPlasma
App Note / Case Study

Sensitive Analysis of a PROTAC Degrader in Rat Plasma

Proteolysis targeting chimera (PROTAC) degraders are used to treat drug-resistant targets via targeted protein degradation.
Rare Cell Discovery With a High-Plex Imaging Platform content piece image
App Note / Case Study

Rare Cell Discovery With a High-Plex Imaging Platform

Rare cells play pivotal roles in disease initiation, maintenance and progression. Yet, identifying these cells remains a difficult task for low-plex technologies, as it is not always clear a priori which biomarkers distinguish rare phenotypes from the remaining population.
Cell Painting High-Content Screening Assay content piece image
App Note / Case Study

Cell Painting High-Content Screening Assay

In drug screening, conventional high-throughput applications evaluate only a few measurements and have limited breadth to detect diverse phenotypic changes caused by compound exposure.
Effortlessly Analyze Pyruvate Kinase Inhibitors content piece image
App Note / Case Study

Effortlessly Analyze Pyruvate Kinase Inhibitors

Pyruvate kinase is an enzyme involved in energy-supplying glycolysis and ATP synthesis, thus is pivotal for the eucaryotic energy metabolism. In addition, overexpression of pyruvate kinase is believed to play a role in cancer.
An LC-MS/MS Toxicology Workflow for Screening Drugs content piece image
App Note / Case Study

An LC-MS/MS Toxicology Workflow for Screening Drugs

One of the major challenges faced by most toxicology laboratories is analyzing hundreds of drugs of abuse in biological samples. This is further complicated by the constantly increasing emergence in the volume of designer and illicit drugs.
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