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Latest App Notes & Case Studies

A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum content piece image
App Note / Case Study

A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum

RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging.
Microflow Chromatography: A Key to More Sensitive Metabolite Identification content piece image
App Note / Case Study

Microflow Chromatography: A Key to More Sensitive Metabolite Identification

In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Preclinical Quantification of Trastuzumab in Rat Plasma content piece image
App Note / Case Study

Preclinical Quantification of Trastuzumab in Rat Plasma

In quantifying therapeutic peptides and proteins in biological matrices, traditional ELISA-only based techniques can suffer from high variability, narrow dynamic range, problems with selectivity and typically cannot use internal standards.
Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis content piece image
App Note / Case Study

Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis

Sample preparation and alternative chromatography techniques are often used to meet the sensitivity needs required in routine bioanalytical assays, but these methods can be time consuming.
Cyclic Peptide Quantitation in Human Plasma content piece image
App Note / Case Study

Cyclic Peptide Quantitation in Human Plasma

In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.
Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry content piece image
App Note / Case Study

Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry

Demands for improved sensitivity in routine bioanalytical assays continue to increase as drug discovery and development programs focus on more efficacious, lower dosage compounds. Pharma development scientists supporting this work therefore require highly sensitive and selective bioanalytical methods for quantification.
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates content piece image
App Note / Case Study

Early Screening of Pancreatic Cancer Immunotherapy Target Candidates

It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
Accelerating Target Validation for Therapeutics With Engineered Cell Libraries content piece image
App Note / Case Study

Accelerating Target Validation for Therapeutics With Engineered Cell Libraries

One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
Automated Protein Sample Preparation in Regulated Environments content piece image
App Note / Case Study

Automated Protein Sample Preparation in Regulated Environments

Download this application focus to learn more about the benefits of automated sample preparation for drug development.
Detection and Characterization of Mitochondrial Toxicity content piece image
App Note / Case Study

Detection and Characterization of Mitochondrial Toxicity

A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity

Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.
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