Latest App Notes & Case Studies
App Note / Case Study
Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry
Demands for improved sensitivity in routine bioanalytical assays continue to increase as drug discovery and development programs focus on more efficacious, lower dosage compounds. Pharma development scientists supporting this work therefore require highly sensitive and selective bioanalytical methods for quantification.
App Note / Case Study
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates
It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
App Note / Case Study
Accelerating Target Validation for Therapeutics With Engineered Cell Libraries
One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
App Note / Case Study
Automated Protein Sample Preparation in Regulated Environments
Download this application focus to learn more about the benefits of automated sample preparation for drug development.
App Note / Case Study
Detection and Characterization of Mitochondrial Toxicity
A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity
Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.
Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.
App Note / Case Study
Kinetic Curvature: Assessment of Small Molecule Kinetics and Affinity
Surface plasmon resonance (SPR) is a core technology used in many pharma and biotechnology settings for this purpose, however traditional initial SPR screening of weak affinity compounds using a single fixed concentration injection can present numerous challenges.
App Note / Case Study
CRISPR Engineered Cells Enable Variant Disease Modeling
Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.
App Note / Case Study
Analysis of Lipid Nanoparticle Composition
In recent years, interest in lipid nanoparticle (LNP) research has increased due to promising opportunities for RNA-based therapy and gene-editing technology, and LNPs are showing promise as nucleic acid delivery vehicles in the pharmaceutical industry.
App Note / Case Study
Cell Painting for Phenotypic Screening
Cell painting is a powerful phenotypic screening method used to gain a deeper understanding of the effects of chemical and genetic perturbagens on cells.
App Note / Case Study
From Mammalian Cell Cultures to Pure Proteins: Reduce Your Cell Harvest Time
For therapeutic applications, it is important that protein production from mammalian cell lines is efficient and pure.
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