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Latest App Notes & Case Studies

Effortlessly Analyze Pyruvate Kinase Inhibitors content piece image
App Note / Case Study

Effortlessly Analyze Pyruvate Kinase Inhibitors

Pyruvate kinase is an enzyme involved in energy-supplying glycolysis and ATP synthesis, thus is pivotal for the eucaryotic energy metabolism. In addition, overexpression of pyruvate kinase is believed to play a role in cancer.
An LC-MS/MS Toxicology Workflow for Screening Drugs content piece image
App Note / Case Study

An LC-MS/MS Toxicology Workflow for Screening Drugs

One of the major challenges faced by most toxicology laboratories is analyzing hundreds of drugs of abuse in biological samples. This is further complicated by the constantly increasing emergence in the volume of designer and illicit drugs.
A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum content piece image
App Note / Case Study

A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum

RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging.
Microflow Chromatography: A Key to More Sensitive Metabolite Identification content piece image
App Note / Case Study

Microflow Chromatography: A Key to More Sensitive Metabolite Identification

In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Preclinical Quantification of Trastuzumab in Rat Plasma content piece image
App Note / Case Study

Preclinical Quantification of Trastuzumab in Rat Plasma

In quantifying therapeutic peptides and proteins in biological matrices, traditional ELISA-only based techniques can suffer from high variability, narrow dynamic range, problems with selectivity and typically cannot use internal standards.
Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis content piece image
App Note / Case Study

Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis

Sample preparation and alternative chromatography techniques are often used to meet the sensitivity needs required in routine bioanalytical assays, but these methods can be time consuming.
Cyclic Peptide Quantitation in Human Plasma content piece image
App Note / Case Study

Cyclic Peptide Quantitation in Human Plasma

In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.
Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry content piece image
App Note / Case Study

Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry

Demands for improved sensitivity in routine bioanalytical assays continue to increase as drug discovery and development programs focus on more efficacious, lower dosage compounds. Pharma development scientists supporting this work therefore require highly sensitive and selective bioanalytical methods for quantification.
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates content piece image
App Note / Case Study

Early Screening of Pancreatic Cancer Immunotherapy Target Candidates

It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
Accelerating Target Validation for Therapeutics With Engineered Cell Libraries content piece image
App Note / Case Study

Accelerating Target Validation for Therapeutics With Engineered Cell Libraries

One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
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