A Guide to Measuring Drug-Target Residence Time
Application Note Aug 29, 2018
During drug development initiatives, analysis of drug-target residence times can lead to improved efficacy. Therefore, residence times are increasingly being used to prioritize molecules early in lead discovery.
This guide provides technical background on concepts and techniques for using Transcreener biochemical assays to measure drug-target residence times in a high throughput format.
Download this guide to learn more including
-The basics of residence time and its importance to drug discovery
-A comparison of methods used for residence time determination
-Using the jump-dilution method with Transcreener Assays
-Examples of determining residence time for kinases, phosphodiesterases, and glycosyltransferases
-Measuring residence time in an HTS compatible format