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A Kinase Inhibitor Phenotypic Screen Using a Multiplex T Cell Activation Assay

T cells and their receptors (TCRs) play a critical role in adaptive immune responses. As a result, the modulation of TCR signaling pathways is highly relevant to many therapeutic areas, including cancer immunotherapy and adoptive cell therapy.

The discovery and development of small molecules and antibodies targeting T cell function, as well as T cell-based cell therapies and cell manufacturing, require assays to rapidly and reliably profile T cell activation and cell health.

In this app note, discover how phenotypic screening addresses these needs, with a single assay providing rapid, optimized monitoring of:

  • Cell proliferation
  • Activation markers
  • Cytokines