We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Studying the Link Between Cell Migration and Neurodegenerative Disease With iPSC-derived Microglia

Microscopic view of fluorescently labeled cells showing green cell bodies with blue nuclei connected by thin, bridge-like structures
Credit: iStock

Microglia, the resident immune cells of the brain, are intimately involved in safeguarding and fortifying neurons against harm.

However, mounting evidence indicates that chronic activation of microglia can create a neurotoxic environment, potentially driving pathological processes in neurodegenerative diseases like Alzheimer’s.

In this application note, researchers from Medicines Discovery Catapult (MDC) used iPSC-derived microglia derived from opti-ox deterministic reprogramming to study the mechanics of microglia activation, shedding light on their role in neurodegeneration and their potential as therapeutic targets.

Download this app note to learn about:

  • Functional, consistent and scalable iPSC-derived microglia that allow for rapid and accurate modeling of neurodegenerative diseases
  • How to measure the chemotaxis of these cells in response to disease-relevant stimuli
  • The complex mechanisms of microglial activation and chemotaxis in conditions like Alzheimer’s
Brought to you by

Download this App Note for FREE Below!
Information you provide will be shared with the sponsors for this content. Technology Networks or its sponsors may contact you to offer you content or products based on your interest in this topic. You may opt-out at any time.