Analysis of Lipid Nanoparticle Composition

In recent years, interest in lipid nanoparticle (LNP) research has increased due to promising opportunities for RNA-based therapy and gene-editing technology, and LNPs are showing promise as nucleic acid delivery vehicles in the pharmaceutical industry. However, to ensure the safety and efficacy of the final drug product, the lipid components need analytical characterization of composition, ratio and degradation.

Download this app note to learn how an UHPLC method can:

• Allow for optimal separation of the four LNP components
• Enable universal detection of lipid components
• Provides superior flow dynamics with its superficially porous base particle