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Detection and Characterization of Mitochondrial Toxicity
Application Note

Detection and Characterization of Mitochondrial Toxicity

Detection and Characterization of Mitochondrial Toxicity
Application Note

Detection and Characterization of Mitochondrial Toxicity

A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity

Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury. This means that sensitive, specific and accurate detection of mitochondrial toxicity is a key consideration during the development of therapeutic compounds.

Download this app note to learn more about: 

  • How to measure the mitochondrial toxicity and identify the mode of toxicity with a single assay by using Mito Tox Index (MTI)
  • Examples of screening experiments using a 240-compound library with Zā€™ > 0.5
  • Software tools that simplify assay template creation and data analysis for screening and dose-response studies.
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