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Evaluation of PARP Inhibitors: Performed on BMG LABTECH’s FLUOstar Omega
Application Note

Evaluation of PARP Inhibitors: Performed on BMG LABTECH’s FLUOstar Omega

Evaluation of PARP Inhibitors: Performed on BMG LABTECH’s FLUOstar Omega
Application Note

Evaluation of PARP Inhibitors: Performed on BMG LABTECH’s FLUOstar Omega

Summary

Poly (ADP-ribose) polymerases (PARP) transfer ADP-ribose to itself and other nuclear proteins such as histones, therefore PARP play a crucial role in regulating DNA repair. A luminescent cellular PARP assay and a fluorescent cell viability assay were performed on BMG LABTECH’s FLUOstar Omega to evaluate PARP inhibitors. PARP inhibition has been demonstrated to potentiate the cytotoxicity of anti-cancer drugs and ionising radiation. The ability of the FLUOstar Omega to measure absorbance, luminescence and fluorescence, facilitates simple, rapid measurements using a single instrument.

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