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Fragment-Based Drug Discovery (FBDD) with Injection Methodologies [Application Note]

Fragment-based drug design has become an increasingly popular platform for the identification of lead candidates in drug discovery programs.

Over the last decade approaches such as nuclear magnetic resonance (NMR), X-ray crystallography, differential scanning fluorimetry (DSF), and surface plasmon resonance (SPR) have become core technologies in many pharma and biotech settings for the identification of these low-affinity fragment compounds.

This application note describes how the dynamic injection SPR (diSPR) technique, marks a quantum innovation in characterizing molecular interactions.