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Metabolic Preconditioning for Improved CAR-T Cell Therapy

Metabolic Preconditioning For Improved CAR-T Cell Therapy content piece image

Metabolism is a key driver of CAR-T cell fitness and function. Hence, metabolic preconditioning methods can enhance the bioenergetic capacity of CAR-T cells in culture, supporting their persistence and antitumor activity.

This app note presents an optimized, in vitro approach for the characterization of CAR-T cell metabolic preconditioning. It demonstrates cell potency and bioenergetic assays that can be used to measure critical process parameters in the manufacturing of effective CAR-T cell therapies. 

Download this app note to learn about a workflow that:

  • Provides confirmatory results from a single, simple approach
  • Yields quantitative information about the killing kinetics and metabolic profile of preconditioned CAR-T cells 
  • Delivers real-time potency results with minimal hands-on setup. 



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