We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Multi-Attribute Method for CQA Monitoring

Multi-Attribute Method for CQA Monitoring content piece image

The Thermo Scientific HR Multi-Attribute Method (MAM) is a powerful high-resolution accurate mass (HRAM)-based workflow that enables comprehensive characterization and monitoring of quality attributes from research to quality control (QC).

The HR MAM enables identification, quantitation, and monitoring of multiple CQAs simultaneously as well as NPD in a verified workflow, serviced and supported by MAM experts from a single vendor.

Learn more about the optimization of this workflow in this application note. This work will also include and discuss:

  • NISTmAb standard CQAs monitoring including glycosylation, deamidation, isomerization, succinimide formation, oxidation and C-terminal lysine truncation, N-terminal pyroglutamate, and glycation
  • Comparison of normal and stressed conditions
  • Illustration of new peak detection (NPD) using spiked and stressed samples