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Novel Organoid Platform for High-Throughput Drug Discovery

Novel Organoid Platform for High-Throughput Drug Discovery
credit: iStock

Studies show that patients and their derived organoids (PDOs) respond similarly to drugs. PDOs are therefore an advanced and biologically relevant in vitro model for the prediction of therapeutic efficacy and toxicity.

However, challenges such as assay reproducibility, scalability and cost have limited the use of PDOs in mainstream drug discovery pipelines.

This app note highlights the utility of highly standardized, assay-ready PDOs in high-throughput applications.

Download this app note to learn how to:

  • Reduce organoid model culture time using assay-ready, PDOs
  • Detect organoid morphological changes over time in response to compound exposure
  • Create robust, automated image analysis pipelines with deep-learning tools for morphological readouts

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