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Oligonucleotide Purity Analysis With Side-Product Identification and Quantitation

Gene Helix

Oligonucleotides play a crucial role in modern drug development, therefore their accurate characterization is essential. However, given the sheer complexity and diversity of the types of oligonucleotides that are in clinical development, a range of diverse analytical approaches are necessary.

This app note highlights a solution using MS technology that can provide an in-depth analysis of oligonucleotides, ensuring identity confirmation, purity determination and synthesis side product identification. 

 

Download this app note to discover:

  • How to enhance oligonucleotide analysis accuracy
  • The benefits of using UHPLC for efficient separation of oligonucleotide impurities
  • Automatic, meaningful reports to reduce analysis turnaround time
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