We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Reach New Levels of Metabolite Characterization

Reach New Levels of Metabolite Characterization content piece image

Early ADME studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. Glucuronide conjugation is difficult to characterize using MS/MS alone, therefore fragmentation is also required to obtain structural information. 

Electron-activated dissociation (EAD) is an orthogonal fragmentation technique that can generate fragments of glucuronide conjugates that retain the glucuronic acid group, allowing for a confident assessment of the conjugation site. 

Download this app note to:

  • Obtain richer fragmentation patterns
  • Generate diagnostic spectral peaks for labile fragments
  • Confidently differentiate between conjugation sites

Brought to you by
Access this App Note for FREE Now!