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Sensitive Analysis of a PROTAC Degrader in Rat Plasma

Sensitive Analysis of the Proteolysis Targeting Chimera (PROTAC) Degrader ARV-110 in Rat Plasma


Proteolysis targeting chimera (PROTAC) degraders are used to treat drug-resistant targets via targeted protein degradation. PROTACs reach complete efficacy at low dosages compared to conventional small molecules, therefore highly sensitive bioanalytical techniques are needed to perform pharmacokinetic and pharmacodynamic studies to evaluate product safety and efficacy.


Download this app note to discover a system that can:


  • Enable a lower limit of quantification of 5 pg/mL for ARV-110
  • Increase productivity with a user-friendly interface and integrated platform for data acquisition, processing and management
  • Achieve outstanding accuracy, precision and linearity for the analysis of PROTACs
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