We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Target-Class Selectivity Profiling for Deubiquitinase (DUB) Inhibitors

Target-Class Selectivity Profiling for Deubiquitinase (DUB) Inhibitors content piece image

Target selectivity is a critical parameter in evaluating potential small molecule drugs and tool inhibitors. For drugs, potent and selective binding of the intended target is associated with efficacy, while promiscuous binding to numerous off-targets is associated with toxicity. For tool inhibitors, knowledge about the target profile is integral in deciphering biological phenotypes and compound mechanism-of-action. Thus, selectivity profiling is an integral step in the drug discovery/ development process.

Download this app note to discover a solution that provides:

  • Accurate quantification with multiplexed stable isotope reagents
  • Unprecedented coverage of cellular DUB enzymes
  • Evidence that hits in a high-throughput biochemical screen are indeed selective for intended targets