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Two-Dimensional Isolation of Target Compounds From Complex Natural Products

Natural products present a major resource for the investigation of naturally occurring biologically active compounds, for example, during lead identification in drug discovery. Two-dimensional liquid chromatography (2D-LC) allows the isolation of high‑purity target compounds from complex natural samples. To date, mostly offline 2D-LC is used for two-dimensional purification, which is time-consuming, difficult to automate, and can incur sample loss or contamination.

Download this app note to discover how online 2D-LC can help you with:

  • Isolating high-purity target compounds
  • Complex natural samples
  • Avoiding manual errors