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Latest Articles

The Evolving Field of Cancer Biomarkers
Article

Given the complexity of cancer, it’s arguably unlikely that single molecules will work as clinically meaningful biomarkers for cancer. Today, biomarker discovery involves detecting patterns – characteristics or phenotypes that can be measured and monitored throughout a patient’s journey. Here, we look at two approaches being explored in this evolving field.

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Sensitivity vs Specificity
Article

When developing diagnostic tests or evaluating results, it is important to understand how reliable those tests and therefore the results you are obtaining are. By using samples of known disease status, values such as sensitivity and specificity can be calculated that allow you to evaluate just that.

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A Further Dimension to Drug Discovery: Combining 3D Culture With iPSCs
Article

Running in parallel with advances in 3D cell culture is the growing use of human cells derived from induced pluripotent stem cells. Researchers are interested in testing drugs in the most physiologically relevant models possible, so it was only a matter of time before these two approaches converged – providing optimized systems for disease modeling and drug toxicity testing.

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Preclinical Modeling of Tumor Metastasis and Resistance: Current Challenges and New Approaches
Article

To improve cancer survival rates, pharma and biotech researchers must develop safe and effective therapies to treat not only primary tumors, but also metastatic growths and tumors that have acquired resistance.

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The Power of Proteogenomics in Precision Medicine
Article

Part of the "systems biology" trend, proteogenomics is expanding at an accelerating rate. In this article, we look at the approaches adopted in proteogenomics and explore how proteogenomics is changing the dynamics of precision medicine in oncology.

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How Drug–Diagnostic Co-development is Shaping Discovery Research and Pharmacotherapy
Article

This article reviews the importance and requirements for developing successful drug–diagnostic co-development models. It also highlights current challenges and ongoing efforts to address these issues, bringing us closer towards a more promising future for pharmacotherapy and patient care.

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Post-translational Modifications in Biopharmaceuticals
Article

This article provides insights on the impact of post-translational modifications of biopharmaceutical products on drug development and biotherapeutic formulation.

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Addressing the Underrepresentation of Women in Science
Article

We recently spoke with Jessica Wade, PhD, a physicist at Imperial College London to learn more about her extraordinary efforts to raise the profile of female scientists and other underrepresented groups in science.

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Incentivizing Drug Development for Rare Diseases
Article

On Rare Disease Day 2019, we discuss how regulatory incentives are necessary for encouraging rare disease drug development, and share the testimonial videos from this year's international campaign.

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The Hunt for Therapeutic Antibodies
Article

Given the clinical success that antibodies (formerly known as “magic bullets”) have facilitated, the drug discovery field continues to search for new therapeutic candidates. This article highlights several techniques used in the process, and touches on current trends driving the field.

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