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Latest Articles

Cell Signaling in Cancer
Article

This article discusses the relationship between cell signaling and cancer, highlights key signaling pathways involved in cancer, and explores how critical mediators of aberrant signaling can be turned into therapeutic targets for cancer.

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Discovering Druggable Targets
Article

We recently spoke to Dr Kilian V. M. Huber from the Structural Genomics Consortium & Target Discovery Institute, University of Oxford to find out – ‘What makes a good target?’.

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Target Identification & Validation in Drug Discovery
Article

This article highlights the properties of an attractive drug target, outlines the approaches used to identify targets, and discusses the key steps involved in target validation and the benefits and challenges of using siRNA to validate targets.

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Light Sheet Imaging Helps Capture Zebrafish Neural Development
Article

A video showing the birth of an incredible network of neurons in the nervous system of a Zebrafish has won first prize at the Nikon Small World in Motion Awards, which highlight the best in photography and video captured through the microscope lens. We caught up with researchers behind the video to find out more.

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One-Pot Reactions: Synthesizing Natural Product Analogs for Drug Discovery
Article

Scientists have discovered powerful new reactions for the synthesis of nature-inspired privileged structures – one-pot, modular, elegantly designed chemical reactions that could minimize the gap between the chemical and biological space. Their study findings could be a turning point for the discovery of unmet diseases.

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Drug Screening: Cellular proliferation assay performed inside a mouse
Article

Although many new cellular assays entered the drug discovery scene over the course of the last decades, we still lack a predictable tool when it comes to selecting compounds or cell lines for xenograft testing. What is lacking?

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Emerging Classes of Next-generation Biotherapeutics
Article

We are entering uncharted territory in biopharmaceutical development. Emerging new classes of treatments are harnessing the natural power of viruses and cells and engineering them to fight human diseases. As our arsenal of conventional therapies begins to fail, a new army of biotherapeutics is on the horizon. Here, we look at two new classes of treatments leading the charge.

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High-Throughput LC-MS for Early Drug Screening and Biomarker Detection
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In this article, we explore two novel high-throughput analytical methods based on liquid chromatography-mass spectrometry (LC-MS) analysis that can augment early drug screening and biomarker detection in the clinic.

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Liver Spheroids: A Major Step Towards Meaningful In Vitro Testing for Human Hepatotoxicity Potential
Article

The development of new in vitro models to replace in vivo testing has already proven quite successful for certain targets. Among these are models of the immune system and human skin, while in vitro cardiac arrhythmia models are poised to emerge in the near future. Despite this clear progress, an efficient model for liver organ toxicity testing still remains elusive.

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Medical Devices: How to Master New Clinical Evaluation Report Criteria
Article

To achieve regulatory compliance and authorization for sale in Europe, every medical device must be supported by a Clinical Evaluation Report which documents the entire clinical evaluation process. Read on for recommendations on how manufacturers can keep up with the changing regulation landscape.

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