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Latest Articles

Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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Through the Looking Glass of Single Cell Proteomics
Article

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

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Microfluidic Diagnostic Tools: Could Doctors Soon Be Obsolete?
Article

The world of microfluidics has generated a host of intricate tools on a microscale, ranging from cheap paper-based lateral flow tests to organ-on-a-chip models designed to facilitate personalized diagnostic tests.
This article explores the extent to which microfluidic tools are filling a gap in clinical and point-of-care diagnostics, and touches on how microfluidics could improve the drug discovery process.

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Unlocking the Secrets of Brain Organization -in the Fruit Fly
Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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Chemical Snapshots and Molecular Maps with Mass Spec Imaging
Article

Mass spectrometry imaging (MSI) is a powerful tool increasingly being used in many fields including cancer research, biomarker discovery and drug development. This article explains why MSI is the technique of choice in many labs, discusses its use in research, and covers how some inherent challenges are being addressed.

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MALDI Imaging Mass Spectrometry (MALDI IMS): A Marriage of Mass Spectrometry and Morphological Spatial Resolution
Article

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a powerful analytical technique that enjoys the sensitivity of mass spectrometry coupled with spatial distribution information.

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Lab Automation Increases Repeatability, Reduces Errors in Drug Development
Article

New technologies are driving laboratory automation to improve efficiency, shorten time to FDA approval and reduce the number of technicians needed in the lab – driving overall development costs down.

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Using Therapeutic Antibodies Against Alzheimer’s Disease
Article

What if immunotherapy was the solution to cure Alzheimer’s disease (AD)? AD represents a major health issue as it affects an increasing number of people each year. The search for a therapy against AD is uncertain. Nevertheless, we can hope that the fast-growing advances in biotechnologies could lead to an improvement in diagnostics and a better understanding of the disease.

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Three Ways to Turn Life Science Suppliers into Partners
Article

A growing number of life science businesses are turning to greater supply chain collaboration for benefits like accelerated time to market, improved quality, reduced risk and more rapid and widespread innovation. But while 68% of executives in this industry say active and meaningful engagement with suppliers is essential to success, far too many, over a third, struggle to implement it.

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Host Cell Protein Analysis in Biopharma
Article

Presence of host cell protein (HCP) contaminants in the final product, even at very low levels, may elicit unpredictable and serious immunogenic response in humans. The accurate detection, identification and quantification of HCPs during biotherapeutic development is thus critical in ensuring patient safety, and is a regulatory requirement.

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