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Incentivizing Drug Development for Rare Diseases
Article

On Rare Disease Day 2019, we discuss how regulatory incentives are necessary for encouraging rare disease drug development, and share the testimonial videos from this year's international campaign.

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The Hunt for Therapeutic Antibodies
Article

Given the clinical success that antibodies (formerly known as “magic bullets”) have facilitated, the drug discovery field continues to search for new therapeutic candidates. This article highlights several techniques used in the process, and touches on current trends driving the field.

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Cell Metabolism and Cancer
Article

It’s almost 100 years since Otto Warburg’s observation that cancer cells metabolize glucose in a manner that is distinct from that of cells in normal tissues. Yet, we still don’t fully understand why. In the years since, significant effort and resource has focused on understanding cancer-specific metabolic changes. Today, attention is also turning to the metabolic interaction between a tumor and its host.

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Pharmaceutical R&D Powered by MALDI Mass Spectrometry Imaging
Article

In order to design and develop new pharmaceutical compounds, the distribution of drugs and their metabolites in tissues must be determined. The emergence of advanced mass spectrometry techniques, such as MALDI imaging, have been pivotal in advancing the field.

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Pluripotent Stem Cells in Drug Discovery: Can We Stem the Tide of Unsuccessful Drugs?
Article

Stem cells were first discovered in human cord blood in 1978. Why would we think they can be of more help now? This article delves into reasons behind the sudden interest in stem cells, and highlights how they can be used to advance drug discovery.

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Addressing Controversy in ADHD: An Interview with Russell A. Barkley, PhD
Article

We interviewed Russell A. Barkley, PhD, an internationally recognized expert on attention-deficit hyperactivity disorder (ADHD), to gain an insight into the disorder, its portrayal in the media and the future of ADHD research.

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Overcoming the Identification Bottleneck in Untargeted Metabolomics: Combining Technological and Software Innovations
Article

Untargeted metabolomics approaches are allowing previously unreported insights into the pathogenesis of disease. However, identifying the large numbers of unknown and structurally diverse metabolites typically present in biological samples has proven to be a major bottleneck. Fortunately, recent advances in technology and software are helping to overcome this challenge.

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UK Lung Cancer Diagnostic Services: Time to Step Up
Article

The UK’s national health system needs to take a hard look at their priorities and procedures to ensure that rapid advances in molecular diagnostics in lung cancer are translated into a practical service for all patients, according to a report launched at the British Thoracic Oncology Group Annual Conference.

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Recent Advances in Liquid Biopsy for Cancer
Article

Liquid biopsies for cancer search for evidence of disease biomarkers, the most common of which include circulating tumor cells, cell-free nucleic acids, exosomes, proteins and phosphoproteins. Read on for insights on advances in the field that could revolutionize clinical oncology practice.

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A Renaissance for Microflow Liquid Chromatography Mass Spectrometry?
Article

First developed in the 1970s, recent developments are making microflow liquid chromatography techniques more robust – enticing researchers to revisit the opportunities it offers for more sensitive, high-throughput analyses requiring smaller sample volumes than standard flow techniques.

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