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Big Data Analysis Approaches for Drug Discovery
Article

Big data has long been a buzzword in drug discovery, but as analysis methods become more sophisticated, its potential is beginning to be realized. We look at some of the latest advances in big data analysis for drug discovery.

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Overcoming Challenges in Biopharma: Transformational Innovation is Key
Article

Looking at the industry growth and the complexities of biopharma development, it is no wonder that transformational developments are required to better equip laboratories and operations in biopharma.

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Quantifying Minimal Residual Disease in Chronic Myeloid Leukemia
Article

Thanks to advances in therapeutics, chronic myeloid leukemia has been transformed from a deadly cancer into a manageable, chronic condition. However, patients have to stay on these drugs their whole lives, as there isn't a diagnostic test sensitive enough to detect traces of the disease that threaten a relapse. This article delves into the unmet need for such a test, and explains why droplet digital PCR (ddPCR) is a strong candidate that may fill this gap.

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Neutrons – A New Weapon Against Cancer
Article

The development of cancer is a complex process, which can result from minor mistakes in an otherwise well-functioning network of cellular processes. As such, it is essential that scientists have a clear picture of biochemical processes at an atomic level in order to gain an in-depth understanding of how various cancers occur and develop. One technique starting to gain recognition as a powerful tool is neutron crystallography.

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The Biochemistry and Pharmacologic Properties of Cannabis-derived Terpenoids
Article

Terpenoids are responsible for the unique aroma of cannabis. These compounds are lipophilic, can permeate lipid membranes, and several are capable of crossing the blood-brain barrier after inhalation. We recently spoke to Ethan Russo, MD, to learn more about the biochemistry and potential pharmacologic properties of cannabis-derived terpenoids.

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Cell Signaling in Cancer
Article

This article discusses the relationship between cell signaling and cancer, highlights key signaling pathways involved in cancer, and explores how critical mediators of aberrant signaling can be turned into therapeutic targets for cancer.

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Discovering Druggable Targets
Article

We recently spoke to Dr Kilian V. M. Huber from the Structural Genomics Consortium & Target Discovery Institute, University of Oxford to find out – ‘What makes a good target?’.

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Target Identification & Validation in Drug Discovery
Article

This article highlights the properties of an attractive drug target, outlines the approaches used to identify targets, and discusses the key steps involved in target validation and the benefits and challenges of using siRNA to validate targets.

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Light Sheet Imaging Helps Capture Zebrafish Neural Development
Article

A video showing the birth of an incredible network of neurons in the nervous system of a Zebrafish has won first prize at the Nikon Small World in Motion Awards, which highlight the best in photography and video captured through the microscope lens. We caught up with researchers behind the video to find out more.

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One-Pot Reactions: Synthesizing Natural Product Analogs for Drug Discovery
Article

Scientists have discovered powerful new reactions for the synthesis of nature-inspired privileged structures – one-pot, modular, elegantly designed chemical reactions that could minimize the gap between the chemical and biological space. Their study findings could be a turning point for the discovery of unmet diseases.

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