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Inhaled Nanobodies: A Potential Treatment for COVID-19
Dr. Yi Shi, assistant professor in the department of cell biology at the University of Pittsburgh and colleagues are exploring the potential of nanobodies as a treatment for COVID-19. The team recently published findings from preclinical studies on the use of a nanobody called Pittsburgh inhalable Nanobody-21 (PiN-21) that targets the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein.
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Closer Relationships Between Sponsors and Regulators Could Transform Clinical Trials
Both pharmaceutical companies and regulators have collaborated closely over the course of the COVID-19 pandemic to develop vaccines, diagnostic tests and other therapies quicker than ever before and have shown us that clinical development can be accelerated. However, there are still several long-standing barriers to progress, when the focus isn’t on a global pandemic, that must now be remedied.
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New Developments in Multiplexing Aim To Reduce Immunoassay Variability
Immunoassays are used for a wide variety of proteomic and genomic applications in drug discovery and development. In this article, we discuss the advantages of multiplexing over single-plex methods and highlight key considerations when developing a multiplex assay.
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Another Psychedelic and Its Potential Psychiatric Promise
Despite the excitement about adding psychedelic substances to psychiatrists’ toolkits, one of the most potent psychedelic compounds available, DMT (N,N-dimethyltryptamine), has received very little attention from clinicians until recently. This article discusses the science of DMT and explores its potential as a therapeutic.
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Cerebral Cavernous Malformation: Moving Away From Surgery, Exploring Alternate Treatments
Technology Networks spoke to Douglas Marchuk, PhD and Daniel Snellings of Duke University School of Medicine to find out more about the current state and future prospects of CCM treatment.
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Turning On the Vaccine Tap – The Challenges of Scaling Up Manufacturing
Science writer Anthony King takes a close look at how each of the authorized COVID-19 vaccines are made, and the challenges faced when working to vaccinate the global population.
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Mass Spectrometry Brings Resolving Power to Biopharma
In the early 20th century, mass spectrometry (MS) was used to measure the mass of atoms and demonstrate the existence of isotopes. Now, MS is used to study a broad range of molecules including small hydrocarbons, proteins, peptides, carbohydrates and DNA.
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In Vivo vs In Vitro: Definition, Pros and Cons
In this article, we will define the terms in vivo and in vitro and further evaluate the pros and cons of analysis using these methods with detailed examples.
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Nitrosamine Impurities – Understanding Risks, Overcoming Challenges
This article covers the basics of nitrosamines, their related health concerns and key steps taken by health authorities to prevent such product recalls in the future.
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UV-Vis Spectroscopy: Principle, Strengths and Limitations and Applications
Ultraviolet-visible (UV-Vis) spectroscopy is a widely used technique in many areas of science ranging from bacterial culturing, drug identification and nucleic acid purity checks and quantitation, to quality control in the beverage industry and chemical research. This article will describe how UV-Vis spectroscopy works, how to analyze the output data, the technique's strengths and limitations and some of its applications.
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