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Latest Articles

Unlocking the Secrets of Brain Organization -in the Fruit Fly
Article

As many people spent the summer trying to keep the flies away from their fruit-bowls, an international group of scientists published one of the biggest and most important datasets in the field of connectomics to date, the complete 3D electron micrograph volume of the fruit-fly (Drosophila melanogaster) brain.

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Untargeted Profiling of Metabolites: In Search of Cancer Biomarkers and Antibiotics
Article

When you are examining a predetermined set of metabolites (in other words, when you know what you are looking for), targeted approaches can be adopted. But when a comprehensive profile of all the metabolites in a sample, known and unknown, is required, untargeted technologies are the way to go. Here, we look at how how untargeted metabolomics is helping science discover new biomarkers for cancer and natural antibiotic sources.

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Chemical Snapshots and Molecular Maps with Mass Spec Imaging
Article

Mass spectrometry imaging (MSI) is a powerful tool increasingly being used in many fields including cancer research, biomarker discovery and drug development. This article explains why MSI is the technique of choice in many labs, discusses its use in research, and covers how some inherent challenges are being addressed.

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MALDI Imaging Mass Spectrometry (MALDI IMS): A Marriage of Mass Spectrometry and Morphological Spatial Resolution
Article

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a powerful analytical technique that enjoys the sensitivity of mass spectrometry coupled with spatial distribution information.

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Lab Automation Increases Repeatability, Reduces Errors in Drug Development
Article

New technologies are driving laboratory automation to improve efficiency, shorten time to FDA approval and reduce the number of technicians needed in the lab – driving overall development costs down.

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Using Therapeutic Antibodies Against Alzheimer’s Disease
Article

What if immunotherapy was the solution to cure Alzheimer’s disease (AD)? AD represents a major health issue as it affects an increasing number of people each year. The search for a therapy against AD is uncertain. Nevertheless, we can hope that the fast-growing advances in biotechnologies could lead to an improvement in diagnostics and a better understanding of the disease.

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Three Ways to Turn Life Science Suppliers into Partners
Article

A growing number of life science businesses are turning to greater supply chain collaboration for benefits like accelerated time to market, improved quality, reduced risk and more rapid and widespread innovation. But while 68% of executives in this industry say active and meaningful engagement with suppliers is essential to success, far too many, over a third, struggle to implement it.

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Host Cell Protein Analysis in Biopharma
Article

Presence of host cell protein (HCP) contaminants in the final product, even at very low levels, may elicit unpredictable and serious immunogenic response in humans. The accurate detection, identification and quantification of HCPs during biotherapeutic development is thus critical in ensuring patient safety, and is a regulatory requirement.

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Advanced Data Analytics in Pharma: Going Beyond Patterns to Understand the “Why”
Article

Developments in pharmaceuticals have made new treatments available, enhancing quality of life for patients. Advanced data analytics solutions mean treatments are more effective and affordable, and less intrusive. However, these evolutions will mean major changes in how companies function requiring new capabilities for operations and supply chain.

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Binding Kinetics in Drug Discovery
Article

The study of binding kinetics goes back more than a century and is the foundation of pharmacological theory as we know it today. Yet, although the interactions between drug target, endogenous ligands and exogenous potential drugs are highly complex, the kinetics of most approved and clinically effective drugs are markedly similar.

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