CRISPR – The New Space Race?
Recently reported in Nature, Chinese researchers have become the first in the world to inject cells that have been genetically edited with CRISPR in to adult humans.
The trial was carried out by Lu You and his group, based at the Sichuan University in Chengdu. On 28 October, they delivered genetically edited immune cells to a single patient who is suffering with aggressive lung cancer. This patient, and others due to receive the same treatment soon, were selected as chemotherapy radiation therapy and other treatments have failed.
This development represents the latest in a series of firsts for Chinese researchers pioneering the use of CRISPR in biomedical research. Following on from the creation of the first CRISPR-edited human embryos in 2015 and the first CRISPR-edited monkeys in 2014.
The process begins with the extraction of T Cells from the blood of enrolled patients. CRISPR-Cas9 is then used to target and interfere with a specific gene in the cells that encodes a protein known as PD-1. These immune cells are then cultured to increase their number and then injected back into the patient.
PD-1 is of interest because it’s normal function is to limit a cell’s immune response; a function that cancers can take advantage of to proliferate, unchecked. The hope is that with this protein removed the edited cells will be able to attack and defeat the cancer. So far, the results seem promising, and You has confirmed that the initial treatment went well.
PD-1 has previously been exploited as an effective target for the treatment of cancer. In the past, antibodies have been used to neutralize the protein and successfully put lung cancer in check. However, researchers believe that the use of CRISPR will allow them to knock out the gene for PD-1 with greater certainty, therefore improving the efficacy of the treatment. Timothy Chan, an immunotherapy expert from Memorial Sloan Kettering Cancer Center, New York City, told Nature “It will be much more powerful than the antibodies.
The introduction of CRISPR has sparked interest around the world and several similar trials have already been approved in the race to develop clinical applications as soon as possible. Carl June, who specialises in immunotherapy at the University of Pennsylvania, is acting as the scientific advisor for one such trial, due to start in the U.S in early 2017. Speaking to Nature he said “I think this is going to trigger ‘Sputnik 2.0’ a biomedical duel on progress between China and the United States, which is important since competition usually improves the end -product”.
At present, the U.S can be considered to be behind China in this area of research, which may reflect the contrast between China’s broad enthusiasm for biotechnology and America’s caution when developing such contentious technologies. Despite moving so fast, Lu You was keen to express that his research was not a leap of faith and that all possible safety precautions have been put in place.
As with any ground breaking research, the world must wait to see the full results of this trial and those scheduled for the new year, to decide whether the risks taken were worth it.
Please note: The content above may have been edited to ensure it is in keeping with Technology Networks’ style and length guidelines.
Cyranoski, David. “CRISPR Gene-Editing Tested in a Person for the First Time.” Nature (2016): n.pag. Web.
Mass Spectrometry Workflow Solutions Top Lab Managers’ Wish Lists at ASMS 2017Article
Streamlining workflows and easing lab manager “pain points” were common themes at this year’s annual meeting of the American Society of Mass Spectrometry (ASMS).READ MORE
Molecular Cancer Therapeutics: Antibodies for fighting cancerArticle
Learn about novel antibody-based strategies for boosting the immune system to control cancer.READ MORE
Zika Virus Persists in Brain and Lymph Tissue for up to 72 DaysArticle
Study using Rhesus monkeys describes how the Zika virus can hide from the body's immune system in brain and lymph tissue for up 72 days. And also describes the possible mechanism by which Zika causes microcephaly in gestating babies.READ MORE
Comments | 0 ADD COMMENT
BioTech Pharma Summit: Companion Diagnostics & Biomarkers
Oct 26 - Oct 27, 2017
12th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry
Feb 26 - Feb 27, 2018
3rd World Congress on Human Genetics & Genetic Disorders
Oct 20 - Oct 21, 2017