A High-Throughput Solution To Accelerate Drug Discovery

Benefits Redefining high-throughput quantification workflows. image description Quality Quality Deliver high quality Z' values and data quality by minimizing sample handling, reducing carryover, and greatly diminishing the effects of suppressive buffers. Drive key go/no-go decisions earlier in your projects. Go from weeks to a matter of days, all while retaining the precise, information-rich information needed to make decisions about your lead compounds. image description Precision Precision Achieve unparalleled standards of quantification. The Echo MS system provides consistent and precise reproducibility in challenging matrices. Its high specificity enables confidence in results and limits the needs for re-runs, all while saving on reagent costs compared to other technologies. image description Speed Speed Conquer throughput barriers and decrease overall turnaround time with sampling speeds of at least 1 sample per second. Screen substrate and product simultaneously and reduce the number of iterations in your process. With the combined power of Acoustic Droplet Ejection (ADE) and Open Port Interface (OPI), the Echo MS decreases your cost/sample while maintaining the data quality you need. Having data same day is a very big step. In terms of what the decision makers are getting, they are literally shipping the compounds and potentially getting results the same day. Simon WoodHead of Analytical Science, Cyprotex. Macclesfield, UK The System Explore the Echo MS system. Echo MS module A pioneering combination of Acoustic Droplet Ejection (ADE) and the Open Port Interface (OPI) enables ultra-fast, contactless sampling, and worry-free, efficient integration into full automation solutions. SCIEX Triple Quad 6500+ mass spectrometer With its high sensitivity and wide linear dynamic range, the industry-proven SCIEX 6500+ system can deliver accurate quantification of both small and large molecule classes in diverse, complex matrices. 7500 system product tile Testimonials What the experts say... Thomas Hankemeier Speed is very important and in some situations even crucial. If you think about processes where you have to make a decision within hours or less, then it makes a very big difference. Thomas Hankemeier Professor of Analytical Biosciences, University of Leiden, Netherlands Simon Wood Having data same day is a very big step. In terms of what the decision makers are getting, they are literally shipping the compounds and potentially getting results the same day. Simon Wood Head of Analytical Science, Cyprotex. Macclesfield, UK Resource Library PharmaPharma Technical NotesTechnical Notes New Development of an acetylcholinesterase biochemical assay using the SCIEX Echo® MS system Biochemical assays are frequently used in drug discovery to monitor enzyme activity and drug potency. These assays are of particular importance in the assessment of potential safety liabilities of new drug candidates. The accurate and timely reporting of these data is critical for decision making within pharmaceutical research. Here, the SCIEX Echo MS system was used as a detection technique for a routine acetylcholinesterase (AChE) biochemical safety assay. image description PharmaPharma Technical NotesTechnical Notes New Accelerating turnaround time in high-throughput ADME pipelines A short read on AEMS technology for ADME screening. Here we discuss automated method building with existing DiscoveryQuant databases, automated batch submission, and data analysis to take advantage of the speed benefits of the LC-free Echo MS system. image description PharmaPharma Technical NotesTechnical Notes New Up to 10x increased throughput for metabolic stability assays Move metabolic stability studies earlier in your pipeline! The Echo MS system enables high-throughput ADME to run 10x faster than traditional LC-MS/MS techniques with the same reproducibility and quantitative performance. image description PharmaPharma Technical NotesTechnical Notes New Automating high-throughput ADME assays on the Echo® MS system Read how the Echo MS system with LeadScape® Analyze 3.0 software is an excellent HT-ADME solution using very low sample consumption, no LC system components, and low operating costs that can support larger studies, test more lead compounds, and accelerate drug discovery. image description TechnologyTechnology Technical NotesTechnical Notes Rapid MS/MS analysis with Acoustic Ejection Mass Spectrometry (AEMS) SCIEX Echo MS system breaks bottlenecks in quantitative mass spectrometry throughput. Here we demonstrate rapid, chromatography-free MS/MS analysis. It showcases the potential to dramatically change the field of high-throughput analysis. image description PharmaPharma Technical NotesTechnical Notes Accelerated pharmacokinetic profiling and metabolite monitoring using Echo® MS system This technology note demonstrates the utility of this high-throughput solution for early discovery phase studies. The Echo MS system can overcome the analytical bottlenecks of traditional LC-MS solutions through speed and quantitative performance. image description PharmaSynthetic biology Technical NotesTechnical Notes High-throughput metabolite quantification for synthetic biology Here, a quantitative approach for the rapid screening of 90 yeast strains using the Echo MS System was demonstrated, monitoring over 60 metabolites. The goal of publishing this workflow is to demonstrate the ability of the Echo MS System to rapidly screen a biological matrix for key metabolites of interest with significantly reduced analysis times.. image description syntheticPharma Technical NotesTechnical Notes True high-throughput bioanalysis using the Echo® MS System See how the Echo MS system provides throughput benefits for early-stage bioanalytical studies. Minimal and no sample preparation options are compared, with the results showing sample prep is not always necessary to achieve good results. The speed and simplicity of analysis of the Echo MS platform make it an attractive approach for high-turnaround bioanalytical laboratories. image description PharmaPharma Technical NotesTechnical Notes Ultra-fast, accurate and simultaneous quantification of ritonavir and lopinavir in human plasma The Echo MS system redefines quantitative mass spectrometry throughput. Here, the system delivers very sensitive, accurate and reproducible results for the simultaneous quantitative analysis of 2 protease inhibitors in human plasma. The very short analysis time (3 sec/sample) and method robustness enable scaling up the number of samples for such quantitative analysis. image description Synthetic biologySynthetic biology Technical NotesTechnical Notes Rapid quantitative analysis of fermentation broth samples to assess efficiency of engineered yeast strain turnover In the field of synthetic biology, the ability to quickly evaluate thousands of microbe strains to produce target compounds is critically important. Here, the Echo MS system is used to rapidly analyze peptide therapeutics in a common fermentation broth, showing the potential impact of this analytical platform on strain selection turnaround time in addressing this bottleneck. image description