Polymeric Nanoparticles for Oral Chemotherapy
Conference Recording Jul 01, 2013
About the SpeakerDra. Agüeros is PhD in Pharmacy (University of Navarra) 2008 and E-MBA (ESIC) 2011. From 2008 is Researcher in Pharmacy and Pharmaceutical Technology department and Guest Lecturer at the University of Navarra. In 2006 she was a Visiting Scientist in Universitè Paris-Sud 11 (Laboratoire Physico-chimie, Pharmacotechnie et Biopharmacie UMR CNRS 8612).Abstract
The oral route for the delivery of pharmaceuticals is the most widely accepted by the patients. It is also considered by decision-makers in the pharmaceutical industry. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal tract challenging. Oral delivery strategies must confront multiple challenges, including the acid gastric environment, the continuous secretion of mucus and the trans-epithelial transport. Creative strategies based on nanoparticle carriers (v.g. mucoadhesive or mucus penetrating systems) have proved capable of overcome these handicaps. However, so far, such nanoparticles are still unable to target a drug to particular subsets of cells after oral administration. Advances in understanding the importance of nanoparticle characteristics such as size and surface properties in their oral fate may create new opportunities to realize the potential of nanoparticles after oral administration. Advantages and limitations of bioadhesive and mucus-penetrating Gantrez AN- based nanoparticles for oral delivery of anticancer drugs will be exemplified.