Accelerating Drug Discovery and Safety Pharmacology Studies

In this webinar there will be two speakers discussing:

Title:
High-Throughput Functional Evaluation of Melanocortin Compounds at the MC4R-Kir7.1 Complex: Biased Signaling at the Melanocortin 4 Receptor

Title:
CiPA Based Evaluation of Proarrhythmia

Watch now to learn about:

Melanocortin 4 receptors (MC4R) are G-protein coupled receptors (GPCR)
Loss-of-function MC4R mutation are linked to early-onset syndromic obesity
MC4R is the first GPCR reported to functionally directly interact with the inward rectifier potassium channel Kir7.1
Evaluation of validated channel assays and applied them to several drugs with questionable proarrhythmic safety
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19

Speaker Information:

Dr Ciria Hernandez, MD, Ph.D
Assistant Research Scientist, University of Michigan Life Sciences Institute

Yuri Kuryshev
Principal Scientist, Charles River Laboratories

Accelerating Drug Discovery and Safety Pharmacology Studies - User Perspectives

In this webinar there will be two speakers discussing High-Throughput Functional Evaluation of Melanocortin Compounds at the MC4R-Kir7.1 Complex: Biased Signaling at the Melanocortin 4 Receptor and CiPA Based Evaluation of Proarrhythmia.

In this webinar there will be two speakers discussing: