Comprehensive Chemical Solutions: From R&D to Production

Chemicals Chemicals Chemical products & services Supporting bench to production applications for multiple industries Whether you are in research and discovery or planning for scale to commercial manufacturing, Thermo Fisher Scientific has 92,000+ chemicals to choose from through our extensive global network of 3,500+ manufacturers. 80K+ Research-use chemicals 12K+ Production-use, cGMP chemicals What we deliver Our global reach Who we serve Amino acids Acid/Base solutions Biological bu ers Biological reagents Specialty chemicals and materials Cleaning agents & disinfectants Carbohydrates Chromatography column cleaning & preservation Developers Etchants High-purity water Media supplements Minerals and vitamins Organometallics Organic and inorganic reagents Resist (positive/negative) Resist strippers Salts & inorganics Solvents Surfactants & emulsifiers And more North America Europe Asia Pacific Biopharma Diagnostics Electronics Healthcare Industrial Pharma 2 Best Multi-sourcing 3 + Strong Low Better Secondary sourcing 2 Medium Medium Good Single sourcing 1 Weak High Number of sources per chemical Reliability of supply Risk of production delay Safeguard timelines with more than one source of your critical chemicals Consider your sourcing strategy to help ensure the supply security of your most critical and large-volume chemicals. Commitment to sustainability Thermo Fisher Scientific is helping to develop and deliver innovative and environmentally responsible products for our customers. Look for the to see which chemical solutions are designed specifically to support your sustainability goals. Chemicals and services for every step of your bench-to-production journey Sourcing support Availability of raw materials is critical to business success—lengthy lead times and shortened supply of raw materials cannot stand in your way. Accessing our broad portfolio allows you to choose your desired chemicals that help you successfully fulfill your sourcing needs and build your chemical library. Our sourcing team has the global reach to provide support for your chemical sourcing decisions and strategies— primary, secondary, and multi-sources—for your projects in R&D stages through commercialization. Supplier and order management Our expertise of supply chain management helps to ensure the right chemicals—manufactured by Thermo Fisher Scientific or outsourced from our global supplier network—are accessible for your applications. Thereby consolidating your supply chain so your team can focus on other critical elements within your processes. 3 Returnable drums and containers If you are routinely using more than 4 L of solvents and blends, then it might be time to learn more about our returnable drums service. Returnable drums and containers are an ideal choice for handling larger quantities of high purity solvents and blends. Re-usable, stainless steel drums with a closed system can help reduce the amount of solid waste generated, and can prevent the release of flammable or toxic vapors into the air. Ensure your product purity • Returnable drums – protect chemical from external environmental • Moisture sensitive – keep solvents and blends with low water content • Low interactions with the inert packaging – maintaining product purity A safer way to manage and work with solvents and blends • Returnable drums and containers are made from high quality stainless steel, which means that there is no risk of breakage compared to a glass bottle • Flammable or toxic solvent liquids and vapors are not released into the surrounding air Research chemicals & services Bulk chemical services for non-GMP Looking to scale up? Looking to simplify the process by using high-quality chemicals? Looking to adapt packaging to scale? With our extensive portfolio of chemicals, we offer comprehensive solutions for all your chemical needs. Whether you are engaged in initial research or scaling up to full production, we can customize products exclusively for you. Our bulk chemical solutions will allow you to go beyond the catalogue and scale up from grams to hundreds or thousands of kilograms. Custom synthesis Bulk & semi-bulk Mixtures & blends chemicals Customized packaging & specifications Thermo Fisher Scientific Your trusted non-GMP chemical services provider Testing services Reduced waste 4 Custom Chemicals Service Custom blends and synthesis Custom specifications Custom labels Custom packaging & pack size Save time and get better product consistency by letting us prepare your custom-made chemicals at our facilities. Take advantage of our extensive chemical services to define and meet your unique specifications. Use our labeling services to display the right product/batch details to enhance product identification for your laboratory. Get the right product in the packaging material or size that you require. We can facilitate your bulk and custom purchases through timely provision of necessary documentation such as: • Synthesis route • Country of origin • Details of the manufacturer • Supplier qualification and audits • Change control • Document control As a global chemicals business, we operate a Quality and Environmental Management System which complies with the requirements of ISO 9001 and ISO 14001, ensuring that our products and services meet our customers’ expectations. Custom blends and synthesis Whether you’re looking to synthesize complex organic building blocks, create custom solvent blends, optimize your synthesis, or develop a scalable route, we can provide the expertise and knowledge to support your project. Our extensive database of production methods for over 8,000 compounds has been developed through 50 years’ experience in custom manufacturing. Highly competent synthetic chemistry team with over 50 years of experience Strong pedigree in method development to develop emerging technologies Ability to work with air-sensitive materials Ability to carry out reactions over temperature conditions ranging from -70 to 250 degrees centigrade Our custom manufacturing capabilities Custom chemicals service for non-GMP The chemical or reagent itself is only a part of the total package. If your needs differ to our catalog product offerings why not take advantage of our custom chemicals service. Less waste and less disposal costs Our returnable drum system can help reduce the amount of liquid waste generated in your laboratory, thereby reducing environmental impact. • A reusable 200 L returnable drum replaces fifty 4 L bottles and associated packing materials. Almost 200 lbs of glass and cardboard are eliminated by each 200 L returnable drum system – helping to support you meet your corporate sustainability goals • Empty returnable drums are cleaned, maintained and refilled by Thermo Fisher Scientific – saving you time and money Our returnable drums are available in 19 to 1,350 L sizes. Custom packaging and labeling Designed for safety, environmental protection, convenient handling and storage and preservation of product integrity while complying with all relevant regulations. Help improve handling, storage, and product integrity by receiving the exact material you want in the exact packaging you want. In addition, our custom weighing service can provide you with products at a scale from nanogram to ton. 5 cGMP chemicals & services When you are challenged to grow and scale your manufacturing capabilities in preparation commercialization, you are tasked with strategic business decisions to source reliable raw materials to use in a regulated environment and optimize your capacity.Our team of technical specialists in cGMP chemical sourcing and supply chain management can help you achieve quality compliance and prevent process interruptions or delays through our suite of chemical services. We work as an extension of your team to create a reliable chemical supply chain—providing business continuity to help accelerate milestone achievement and speed to market. Production Chemicals and Sourcing Services Access all of the major cGMP chemicals your processes need. Production Chemicals and Sourcing Services enables you to consolidate cGMP chemical orders of multiple brands from various manufacturers to help maximize your resources and protect your timelines. About our cGMP Service Centers • ISO 9001:2015 certified • Validated cGMP/GDP-compliant Quality Management System (QMS) and technology systems • HAZMAT-controlled storage for flammables, corrosives, poisons, and oxidizers • Built-in redundant procedures for consistency of orders • Temperature mapped, controlled, and monitored* • Clean rooms meeting ISO 8 standards* 12K+ GMP-manufactured, multi-compendial chemicals 100+ industry-leading cGMP chemical manufacturers and suppliers accessible around the globe Integrated supply chain capabilities 6 Direct Material Supply Chain Services The right support can make a cGMP supply chain operate seamlessly. Imagine simplifying orders and deliveries without increasing your facility’s footprint or inventory on hand. Thermo Fisher Scientific can help streamline all aspects of your cGMP chemical supply chain management, helping you achieve your milestones faster. Placing the order(s) with multiple suppliers Resolving material issues Managing production schedule Evaluating facility capacity to meet demands Assuming all EH&S risks Reacting to fluctuating lead times Current: You-managed supply chain S u pplier D S upplier C Supplier B Supplier A Order arrival at customer facility Large cGMP-compliant warehouse footprint required for receipt, handling, sampling, and storage Freight Customer pays for freight for each shipment Suppliers Minimal order delivery flexibility, product shipped once manufactured Working directly with suppliers can increase the complexity of your supply chain and tie up valuable resources. cGMP warehouse capacity requirements You-managed FTE resource requirements Cash tied up in inventory Industry observations $5M Average cost to build a cGMP-compliant warehouse $600K Average cost to build a cleanroom 85% OTIF performance industry average when working direct with a supplier 7 Consider how you manage your current cGMP supply chain using this diagram. Assurance of Supply Services Get the GMP-manufactured chemicals you need, when you need them with just-in-time delivery. Assurance of Supply Services helps you meet growing demand so that raw materials are available and delivered to you when you need them. Production Ready Services* Accelerate raw materials quality release. Production Ready Services helps you shorten the QA/QC-release cycle necessary before cGMP chemicals can be brought into production processes through raw material sampling and planning for safety stock inventory. * Currently only available within the United States **Excludes constrained chemicals. Future: Thermo Fisher - managed supply chain Customer working with Thermo Fisher plier D S upplier C Supplier B Supplier A Order arrival at customer facility Reduced warehouse and cleanroom space required and less cash tied up in inventory Freight Lower shipping costs with consolidated freight Supply assurance • Custom stocking agreements • Inventory management Sampling and release • Raw material sampling • QA/QC inspection • Material release labeling Material handling and warehousing • Custom labeling and barcoding • Pallet transfer • Down packing • Dip tube exchange • Safety stock storage Material order and receipt • Supplier relationship management • Order management • Alternative sourcing assistance • Customer-aligned supply management • Multi-step receipt inspection • cGMP-compliant storage Thermo Fisher managed The right support can help make your supply chain operate seamlessly. cGMP Distribution Services Maintain compliance in your deliveries of GMP-manufactured chemicals and reduce transportation emissions by consolidating your supply chain. cGMP Distribution Services helps to ensure that the cGMP quality of your chemical order is maintained in transit to your facility. This service is automatically included in Production Chemicals and Sourcing Services. Warehouse Efficiency Services* Achieve efficiency in receiving, handling, and storing your cGMP chemicals. Warehouse Efficiency Services provides material support including custom barcoding and labeling, poly-palletization, recycling of empty containers, and dip-tube exchange. All our cGMP Service Centers recycle cardboard, as well as returnable drums and containers. With poly-pallet transfer, we recycle the wood pallets or reuse them to send future materials. cGMP warehouse capacity requirements FTE resource requirements Cash tied up in inventory cGMP warehouse capacity requirements FTE resource requirements Cash tied up in inventory cGMP warehouse capacity requirements FTE resource requirements Cash tied up in inventory cGMP warehouse capacity requirements FTE resource requirements Cash tied up in inventory Achieve 90% OTIF performance Achieve >90%* OTIF performance 8 Discover how your cGMP supply chain can achieve a consolidated and simplified future state using this diagram. Scan the QR code to request more information about our chemical products & services. Product and service availability may vary by country and is subject to appropriate or region-specific regulatory requirements. Contact your Thermo Fisher technical specialist for more information at: thermofisher.com/chemicalsolutions. For Research Use Only or Further Manufacturing. Not for diagnostic use of direct administration into humans or animals. It is responsibility of the final formulator or end user to determine suitability, and to qualify and/or validate each product for its intended use. © 2023 Thermo Fisher Scientific Inc. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. EXT5157 0623 Chemicals