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Ketone Shuttle Coordinates Response to Liver Fibrosis
Ketone Shuttle Coordinates Response to Liver Fibrosis
News   Nov 16, 2018

A metabolite shuttle, or dialogue, provides a connection between hepatocyte and macrophage cell types in the liver and helps protect against tissue fibrosis.

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Molecular Mechanisms of Ancient Herbal Remedies
Molecular Mechanisms of Ancient Herbal Remedies
News   Nov 16, 2018

Analysis of leaf extract reveals novel chemistry for therapeutic ion channel activation.

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Scorpion Venom Can Shuttle Drugs into the Brain
Scorpion Venom Can Shuttle Drugs into the Brain
News   Nov 16, 2018

Researchers at IRB Barcelona modify chlorotoxin—a small protein present in scorpion venom with blood-brain barrier permeability—to transport drugs into the brain.

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Leukemia Stem Cells Rely on Amino Acids for Survival
Leukemia Stem Cells Rely on Amino Acids for Survival
News   Nov 16, 2018

Clinically relevant eradication of leukemia stem cells could be achieved with drugs that target their metabolic vulnerabilities.

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New Inflammation Inhibitor Discovered
New Inflammation Inhibitor Discovered
News   Nov 16, 2018

A multidisciplinary team of researchers led from Karolinska Institutet in Sweden have developed an anti-inflammatory drug molecule with a new mechanism of action.

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Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
News   Nov 16, 2018

A new Tel Aviv University study finds that the drug candidate CP201, also known as NAP, may improve vocal communication abilities that are underdeveloped in Activity-dependent neuroprotective protein (ADNP) patients.

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Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
News   Nov 16, 2018

A new approach to analyzing cell membrane proteins in situ could revolutionize the way in which we study diseases, such as cancer, metabolic and heart diseases.

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Rainforest Vine Compound Starves Pancreatic Cancer Cells
Rainforest Vine Compound Starves Pancreatic Cancer Cells
News   Nov 15, 2018

Researchers have identified a compound from a Congolese plant that has strong "antiausterity" potential, making pancreatic cancer cells susceptible to nutrient starvation.

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Dramatic Increase in E-Cigarette Use Among Youth
Dramatic Increase in E-Cigarette Use Among Youth
News   Nov 15, 2018

Sharp rise in e-cigarette use results in uptick in overall tobacco product use; prompts new, forceful steps by FDA to firmly confront and reverse youth epidemic.

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Identifying Alzheimer's Drug Candidates with Anti-aging Properties
Identifying Alzheimer's Drug Candidates with Anti-aging Properties
News   Nov 14, 2018

Old age is the greatest risk factor for many diseases, including Alzheimer's disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.

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