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Amino Acids Regulate How Cells Respond to Drugs
Amino acids work together to regulate the cellular response to certain drugs, which could help develop more effective and safer treatments, according to an international study.

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Previously Overlooked Protein a Potential New Drug Target for Lung Disease
Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have identified a previously overlooked protein, Epac1, as a key driver of idiopathic pulmonary fibrosis (IPF), a chronic and progressive lung-scarring disease.

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Stable Molecular Assemblies Pave the Way for Geometry-Controlled Drugs
Researchers have developed a new family of remarkably stable chiral molecules. This work opens up new prospects for the design of geometry-controlled drugs.

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Penicillin Allergy Testing Could Be Key to Combating Antibiotic Resistance
Removing incorrect penicillin allergy labels on GP records could combat antibiotic resistance and save lives, an NIHR-funded clinical trial led by the University of Leeds has found.

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Molecular Mechanisms Behind Polycystic Kidney Disease Inform Targeted Therapies
Recent research has identified novel molecular mechanisms by which genetic mutations in the PKD2 gene cause the most common form of polycystic kidney disease.

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How Low Blood Sodium Can Amplify the Risks of Heart Rhythm Drugs
Researchers at the Fralin Biomedical Research Institute at VTC, collaborated on a new study revealing why low blood sodium levels can amplify the risks of certain commonly prescribed heart rhythm medications.

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Hormone-Driven High Blood Pressure Reversed by New Drug
Baxdrostat, a drug belonging to a new class of aldosterone synthase inhibitors, led to an average fall in blood pressure of 25 mmHg in clinical trials. This is two to three times the reduction typically achieved by a single antihypertensive drug.

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Lessons on Long COVID From Feline Coronavirus
Scientists have found that mesenchymal stromal cells, or MSC therapy, in combination with antiviral drugs, helped cats’ immune systems recover and reduced systemic inflammation.

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Early Antibiotic Use Alters Infant Immune Development
A new study has found that early-life exposure to antibiotics can impair an infant's developing immune system, and that a naturally occurring metabolite may hold the key to reversing the damage.

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Why Nicotine Withdrawal Feels So Awful – And What Drives It
A study reveals a brain circuit between the interpeduncular nucleus and the laterodorsal tegmentum that drives nicotine withdrawal symptoms. Inhibiting this connection in mice reduced anxiety, restored motivation and boosted dopamine.
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