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Drug discovery.
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Pharmacogenetic Testing Is Now in Action

UC San Francisco will be the first hospital in California, and one of only a few nationwide, to offer pharmacogenetic testing.
A psychedelic scene in the brain.
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A Molecular View of How Magic Mushrooms Bind to the Brain

Psilocybin is a hallucinogenic compound found in about 200 mushroom species, including the liberty cap. For millennia, our ancestors have known and used this substance, and in recent years, it has received renewed interest from scientific researchers and therapists.

A gloved hand with syringe.
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First Human Trial of New Zika Vaccine Commences

The first participant has received a dose of a new Zika virus vaccine being trialled by the University of Liverpool at the Clinical Research Facility within the Royal Liverpool University Hospital.
An x-ray of the chest.
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siRNA Therapy Delivered to the Lungs

Scientists have developed a technology to deliver gene therapy directly to lung tissue through intranasal administration, a development that could potentially create a new class of treatments for lung disease.
A brain scan viewed on a tablet device.
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Breakthrough Procedure Enables Chemotherapy To Enter the Brain

A first-in-human clinical trial has successfully delivered chemotherapy drugs through the blood–brain barrier using ultrasound, with the potential to aid treatment for the deadly brain cancer glioblastoma.
An image depicting a visual hallucination.
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African Psychedelic Plant Inspires Two New Depression Drugs

Modeling the pharmacological properties of the African psychedelic plant medicine ibogaine, researchers have developed two novel drug candidates for treating addiction and depression. The research is published in Cell.
A girl sitting on a chair looking out a window.
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Ketamine Can Alleviate Symptoms of Depression but May Cause Dissociation.

Ketamine can lessen the effects of depression but can also trigger dissociative symptoms—such as detachment and out-of-body experiences.
The inside of an operating room.
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Cancer Drug Toxicity Tested Using Donated Dog Heart Tissue

Researchers have developed a new platform to test cardiac side effects of chemotherapy using donated heart tissue from dogs.
An illustration of a DNA double helix.
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Dual Gene-Editing Strategy To Combat HIV

Gene-editing therapy aimed at two targets – HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells – can effectively eliminate HIV infection.
A woman putting a tablet into her mouth.
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Development of Low-Cost Oral Cholera Vaccine Underway

The International Vaccine Institute (IVI) began clinical development of DuoChol, a new low-cost oral cholera vaccine (OCV) in capsule form.
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