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Possible New Drug Targets Found for Advanced Non-Alcoholic Fatty Liver Disease
Researchers have uncovered a network of cell-to-cell communication driving scarring as liver disease advances, which could lead to novel drug targets for non-alcoholic fatty liver disease.
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Preclinical Study Reveals Promising Triple Immunotherapy for Pancreatic Cancer
A study found that targeting T cells and myeloid cells together as part of combination therapy improved anti-tumor response and survival in preclinical models of pancreatic cancer.
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Microprotein Increases Feeding Activity in Mice
Fat tissues contain thousands of previously unidentified microproteins, one of which has been shown to increase appetite in mice.
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Drug Discovery Could Boost Liver Transplant Success
According to a study, an existing drug could protect donor livers from damage during the transplantation process and reduce complications that occur afterward.
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Inhibiting Enzyme Reduces Bone Metastasis in Cancer Models
An agent that inhibits an enzyme that controls the activity of the cells responsible for building up bone was found to reduce cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice.
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New Antibiotic Is Effective Against Drug-Resistant Bacteria
Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.
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Gene Therapy Gel Helps Old Wounds Heal
People with a blistering skin disease called dystrophic epidermolysis bullosa often suffer from large open wounds that last for years or decades. A double-blind, placebo-controlled clinical trial of a gene therapy gel developed at Stanford Medicine shows improved wound healing in people with the disease.
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Long-Living Chilean Rodent Is Well-Suited for Alzheimer's Research
Degus – long-lived Chilean rodents – have been shown to be a useful and practical model of Alzheimer's disease.
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“Breakthrough” Made in Understanding How Inflammation Is Regulated
Scientists have discovered that Interleukin-37 has an unexpected function as an immune-activating molecule, rather than an "off-switch" as once believed.
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Melanoma Clinical Trial Reveals Success of Drug Combination
A combination of a common immunotherapy drug with all-trans retinoic acid, a chemotherapeutic, has shown promise in clinical trials.
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