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Drug Discovery

Drug Discovery

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A baby laying down.

No Adverse Health Risks From Steroids Used for Pre-Term Birth, Study Finds

A ginger haired woman leaning over the arm of a chair.

Scientists Identify Brain Circuit That Suppresses Appetite During Nausea

Immunotherapy attacking a cancer cell.

Immunotherapy Combination Approved for Non-Muscle Invasive Bladder Cancer

Psilocybin Shows Promise for Treatment-Resistant Depression – But Is It Safe?

Phage Therapies for Multidrug-Resistant Infections Should Consider Host Response

First Use of CRISPR-Cas9 Gene Editing in Kissing Bugs

News

Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Study reveals the CoreSiMMap is useful to identify adaptive SK inhibitors and provide insight into the binding mechanisms of compounds.

Verona Pharma Appoints Manchester Clinical Research Facility to Carry Out Clinical Trial with RPL554

Enrollment of patients to start Q2, with results expected early Q4 2012.

Lipid Therapeutics Licenses European Rights to LT-02 for Ulcerative Colitis

Dr. Falk Pharma GmbH to initiate Phase III trial.

CiToxLAB Increases Inhalation Test Capabilities in North America and Europe

Growth in capacity and capabilities sees CiToxLAB emerge as a major player in the safety assessment of pharmaceuticals and chemicals via the inhalation route.

Macro-to-Micro Structural Proteomics: Native Source Proteins for High-Throughput Crystallization

In this study, researchers from University of California demonstrate the utility of native source proteins for high-throughput crystallography.

Motion and Flexibility in Human Cytochrome p450 Aromatase

X-ray structures of human placental aromatase do not provide accounts of movements in this work, researchers conduct normal mode analysis revealing the intrinsic fluctuations of aromatase.

Global Patterns of Genetic Diversity and Signals of Natural Selection for Human ADME Genes

This study is the first to systematically investigate worldwide population differentiation and potential signals of natural selection in a comprehensive list of ADME genes.

ACADIA Pharmaceuticals Extends Drug Discovery Collaboration with Allergan, Inc.

The collaboration is currently focused on the discovery of new therapeutics for glaucoma and other ophthalmic indications and was originally established in March 2003.

A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity

Researchers from Children's Hospital, Boston report the development of a sensitive and robust but low-tech and inexpensive high-throughput metabolic screen for novel antibiotics.

Simcyp Limited Acquired by Certara

The acquisition makes Simcyp the third member of the Certara group alongside Tripos and Pharsight.

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