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AI Model Accurately Predicts Response to Novel Drug Compounds
Researchers have created an artificial intelligence model called CODE-AE that could significantly improve the accuracy, time and cost of the drug development process. Researchers hope this will accelerate drug discovery and precision medicine.
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New Drug Identified for Triple-Negative Breast Cancer
According to research, a combination of a novel small inhibitory molecule and an FDA-approved chemotherapy drug can suppress the growth of triple-negative breast cancer cells synergistically.
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Targeting Enzyme Could Reduce Muscle Wasting in Cancer Patients
Cancer-induced muscle wasting is a common complication in the late stages of cancer. New research has identified a key enzyme that drives the condition, opening doors to developing treatments.
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Partnership Aims To Improve the Next Generation of TB Vaccines
The National Institutes of Health's National Institute of Allergy and Infectious Diseases has awarded two nonprofit research organizations with a $3.5 million, five-year Innovation for Tuberculosis Vaccine Discovery grant.
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New Insights Into How Breast Cancer Cells Become Resistant to Therapy
Researchers have investigated how breast cancer cells become resistant to endocrine therapy, revealing a mechanism that both explains the process and offers possibilities to overcome it.
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Understudied Protein Could Be a Target for Osteoarthritis Treatment
Researchers have discovered that activating a specific protein in chondrocytes, a critical cell type that maintains healthy cartilage in joints, could restore multiple factors needed for smooth joints, helping to control inflammation.
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Study Suggests Rheumatoid Arthritis Drug Can Be Repurposed for Diabetes
Researchers have discovered that the rheumatoid arthritis drug auranofin can potentially be repurposed to improve diabetes-associated symptoms, following a study in mice.
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Method Identified To Overcome Treatment Resistance in Aggressive Breast Cancers
According to research, a new therapy currently undergoing clinical trials promotes a potent immune response by binding to fibroblasts, enabling it to overcome resistance to anti-HER2 therapy in tumors.
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How a Metabolite Converts “Bad” Fat to “Good” Fat
Researchers used novel drug discovery technologies to uncover a metabolite that converts white fat cells (“bad” fat) to brown fat (“good” fat) cells. This discovery offers a potential way of addressing metabolic conditions like obesity, type 2 diabetes and cardiovascular disease.
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Antibiotic Cement Developed To Prevent Bone Infections After Surgery
Researchers have developed a computer-program-generated library of antibiotics and have used this to identify an effective antibiotic for targeted use in a bone cement matrix.
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