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"Masked" Cancer Drug Activates Once It Reaches the Tumor To Reduce Side Effects
Researchers have long suspected that interleukin-12 could be a powerful cancer treatment, but it can cause unwanted adverse effects. Now, researchers have developed a version of the molecule that remains inactive until it reaches the tumor site.
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New Clinical Trial of Monoclonal Antibody for Asthma
The NIH has launched a clinical trial testing whether a monoclonal antibody, dupilumab, can reduce asthma attacks and improve lung function and asthma symptoms in children with poorly controlled allergic asthma who live in low-income urban neighborhoods.
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Salmonella Vaccine Contributed to Rise of Antibiotic-Resistant Bacteria
Researchers from the University of São Paulo, Brazil and the Quadram Institute Bioscience, UK have conducted an investigation into the evolution of Salmonella bacteria in Brazilian poultry. The study identified that introducing a Salmonella vaccine for poultry – in addition to increasing use of antibiotics by Brazilian farmers – has led to strains evolving that are antibiotic-resistant. These strains are less likely to cause disease in humans.
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Could Athletic Performance Be Linked to Antibiotic Use?
In a mouse study, researchers found that knocking out essential bacteria in the gut microbiome with antibiotics could deflate the will and ability to exercise.
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Blocking Adenosine A2B Receptors Reduces Immunosuppression in Tumors
A team of international researchers has demonstrated that blocking adenosine A2B receptors reactivates the immune system in the tumor microenvironment and demonstrates its effectiveness in cancer immunotherapy.
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“Jumping” Protein Helps To Keep Cells Healthy
There is a lot of potential for RNAi therapeutics, and Cold Spring Harbor Laboratory (CSHL) researchers are working hard to paint a complete picture of the process, to improve therapies today and make better ones tomorrow.
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Investigational Drug Kills Rare Soft Tissue Tumor Cells
Researchers have developed a way to attack synovial sarcoma, a rare tumor of soft tissues, using an investigational drug that triggers cell death.
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New Imaging Approach Provides Detailed Images of Organoids
Researchers have developed a new imaging system to quickly produce high-resolution 3D images in real-time, providing a quantitative analysis of organoids.
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Genetic Sex Determines How Muscle “Talks” to Other Tissues in the Body
A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues and that the organs and processes muscle impacts are markedly different between males and females.
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First Head-to-Head Comparison of Four COVID-19 Vaccines
A new study into how four types of COVID-19 vaccines prepare the body to fight SARS-CoV-2 is the first in history to compare how three different vaccine platforms trigger an immune response against the same pathogen.
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