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New Brain-Permeable Drug Targets Melanoma Brain Metastases
Researchers have demonstrated striking preclinical efficacy of a BRAF inhibitor, C1a, that can cross the blood–brain barrier and has potent activity against melanoma metastases in the brain.
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20 New Case Studies Demonstrate Success of Phage Therapy
20 new case studies have been reported where bacteriophages have been used to treat Mycobacterium infection, with successes in more than half of cases.
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New Chemical-Only Process for Customized mRNA Vaccines
Researchers at Nagoya University in Japan have developed a new chemical-only process that may represent an important breakthrough in creating customized mRNA vaccines for a variety of diseases and allow for the inexpensive preparation of mRNA in large quantities.
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New Candidate Target for Parkinson’s Disease Treatment
Researchers have identified a lipase that degrades triglycerides to produce fatty acids as a candidate therapeutic target for Parkinson's disease.
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New Genetic Eye Disease Discovered
Researchers from the National Eye Institute (NEI) have identified a new disease that affects the macula, a small part of the light-sensing retina needed for sharp, central vision.
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Zinc May Reverse Damage Caused by Lung Disease
A root cause of an age-related lung disease has been identified, revealing that zinc treatment could improve survival for those with idiopathic pulmonary fibrosis.
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Synthetic Receptor Could Alleviate Need for Chemo Treatment Before T-Cell Therapy
Research shows that a synthetic IL-9 receptor allows cancer-fighting T cells to do their work without the need for chemo or radiation.
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“Subtle Change” in Mothers’ Antibodies During Pregnancy Protects Newborns
A research team has discovered that a “subtle change” in the structure of sugars that attach to antibodies during pregnancy enables their protection against a wider variety of pathogens.
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Rectal Cancers “Disappear” in Experimental Drug Trial
Findings confirm a clinical complete response in all 14 patients who received dostarlimab as a first-line treatment for mismatch repair-deficient locally advanced rectal cancer.
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How Genetic Factors Affect the Body’s Immune Response in Type 1 Diabetes
A new study has explored how genetic factors influence immune cells and cytokine production and how this links to susceptibility to type 1 diabetes.
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