News

An international study has shown that the body’s immune system attacks itself in a rare type of blood cancer called large granular lymphocyte (LGL) leukemia. Therefore, treatment strategies should be targeted at the immune system as well as the cancer cells themselves.

A research team has designed a virus that selectively infects cancer cells and causes the infected cells to release RNA-containing extracellular vesicles that blunt the antiviral response of surrounding cancer cells.

Progress in the development of a drug to treat metabolic syndrome has been furthered by identifying a receptor that controls appetite and body weight.

An anti-HIV strategy, called Vectored ImmunoProphylaxis (VIP), MIT and Harvard and Massachusetts General Hospital (MGH) involves using an adeno-associated viral (AAV) vector to deliver instructions to muscle cells to pump out antibodies that block the virus.

Research has revealed that the constant pattern of stretching and relaxing caused by breathing generates immune responses against invading viruses.

A variant of the CTLA-4 gene was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in other lung cancer patients and healthy individuals.

Researchers have discovered how Gram negative bacteria—which cause numerous drug-resistant infections—finish building a crucial component of their outer membrane that shields them from attacks by the immune system and antibiotics.

An oral medication used to treat pancreatitis improved symptoms in trial participants with newly diagnosed with COVID-19. The drug, camostat mesylate, did little to lessen viral load but did appear to prevent loss of smell or taste.

The discovery that gallium maltolate has anticancer activity against glioblastoma in preclinical studies opens the door for developing it as a drug for the treatment of glioblastoma.

Early-stage clinical trials of two drugs that target the DNA damage response pathway in cancers have shown that the drugs are safe and clinically beneficial for treating advanced tumors.