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Immune System Attacks Itself in a Rare Type of Blood Cancer
An international study has shown that the body’s immune system attacks itself in a rare type of blood cancer called large granular lymphocyte (LGL) leukemia. Therefore, treatment strategies should be targeted at the immune system as well as the cancer cells themselves.
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Virally-Programmed Extracellular Vesicles Designed To Shrink Tumors
A research team has designed a virus that selectively infects cancer cells and causes the infected cells to release RNA-containing extracellular vesicles that blunt the antiviral response of surrounding cancer cells.
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Receptor That Controls Appetite and Body Weight Identified
Progress in the development of a drug to treat metabolic syndrome has been furthered by identifying a receptor that controls appetite and body weight.
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Anti-HIV Therapy Yields Promising Phase I Trial Results
An anti-HIV strategy, called Vectored ImmunoProphylaxis (VIP), MIT and Harvard and Massachusetts General Hospital (MGH) involves using an adeno-associated viral (AAV) vector to deliver instructions to muscle cells to pump out antibodies that block the virus.
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Human Lung Chip Helps To Identify Potential Treatments for Respiratory Diseases
Research has revealed that the constant pattern of stretching and relaxing caused by breathing generates immune responses against invading viruses.
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Lung Cancer Patients With Variant of the CTLA-4 Gene May Respond Better to Immunotherapy
A variant of the CTLA-4 gene was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in other lung cancer patients and healthy individuals.
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How Drug-Resistant Bacteria Build Their Protective Shield
Researchers have discovered how Gram negative bacteria—which cause numerous drug-resistant infections—finish building a crucial component of their outer membrane that shields them from attacks by the immune system and antibiotics.
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Drug Seems To Prevent Loss of Smell and Taste From COVID-19
An oral medication used to treat pancreatitis improved symptoms in trial participants with newly diagnosed with COVID-19. The drug, camostat mesylate, did little to lessen viral load but did appear to prevent loss of smell or taste.
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Therapy That "Tricks" Cancer Cells Is Set To Begin Clinical Testing in Glioblastoma Patients
The discovery that gallium maltolate has anticancer activity against glioblastoma in preclinical studies opens the door for developing it as a drug for the treatment of glioblastoma.
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Two Drugs Targeting DNA Damage Response Show Promise in Early-Stage Cancer Trials
Early-stage clinical trials of two drugs that target the DNA damage response pathway in cancers have shown that the drugs are safe and clinically beneficial for treating advanced tumors.
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