Standard therapies for advanced recurring aggressive, hematological malignancies, have a limited effect. A study has demonstrated that therapy selection based on results from a functional test is clinically possible and effective in patients with recurrent hematologic cancers.

Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death.

An increasing number of studies report that proteins do not work in isolation but are part of a complex network of biomolecules, that may differ at various settings or stages of tumor progression.

According to a study, patients with breast, pancreatic and other types of cancer may survive longer if given dexamethasone, an anti-nausea drug, during surgery.

Researchers are focusing on identifying potential host-directed therapies that can target a patient’s own immune response to help them recover from tuberculosis.

A new study conducted using mice suggests that targeting the alpha-synuclein protein may not be sufficient to treat the disease and alleviate symptoms in most patients.

Researchers are hopeful that new understanding of cellular defects related to cystic fibrosis could help pave the way for treatment of the disease.

The investigational Alzheimer’s drug CMS121 has now moved into a Phase I clinical trial to evaluate its safety in humans. In preclinical studies with mice, CMS121 was shown to reverse signs of aging in the brain and could prevent memory loss associated with Alzheimer’s disease.

Researchers have found that a drug first developed to treat Alzheimer’s disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function without changes in food intake or daily activity.

Researchers have identified a small molecule that could, in the future, be administered alongside standard chemotherapy to prevent the spread of colorectal cancer.