Study Using a Functional Test Supports Clinical Feasibility and Efficacy of Personalized Cancer Therapy
Standard therapies for advanced recurring aggressive, hematological malignancies, have a limited effect. A study has demonstrated that therapy selection based on results from a functional test is clinically possible and effective in patients with recurrent hematologic cancers.
New Source of Liver Stem Cells Discovered
Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death.
Using CRISPR-Cas9 To Explore Epigenetic Editing in Different Tumor Settings
An increasing number of studies report that proteins do not work in isolation but are part of a complex network of biomolecules, that may differ at various settings or stages of tumor progression.
Cancer Patients May Live Longer if Given Anti-Nausea Drug During Surgery
According to a study, patients with breast, pancreatic and other types of cancer may survive longer if given dexamethasone, an anti-nausea drug, during surgery.
Improving Treatments for Tuberculosis
Researchers are focusing on identifying potential host-directed therapies that can target a patient’s own immune response to help them recover from tuberculosis.
Drug Target for Parkinson’s Disease May Not Be Relevant for All Patients
A new study conducted using mice suggests that targeting the alpha-synuclein protein may not be sufficient to treat the disease and alleviate symptoms in most patients.
New Insights Into the Cellular Basis of Cystic Fibrosis
Researchers are hopeful that new understanding of cellular defects related to cystic fibrosis could help pave the way for treatment of the disease.
Investigational Alzheimer’s Drug CMS121 Begins Phase I Clinical Testing
The investigational Alzheimer’s drug CMS121 has now moved into a Phase I clinical trial to evaluate its safety in humans. In preclinical studies with mice, CMS121 was shown to reverse signs of aging in the brain and could prevent memory loss associated with Alzheimer’s disease.
Drug Reduces Obesity in Mouse Model
Researchers have found that a drug first developed to treat Alzheimer’s disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function without changes in food intake or daily activity.
A Molecular Monkey Wrench for Cancer
Researchers have identified a small molecule that could, in the future, be administered alongside standard chemotherapy to prevent the spread of colorectal cancer.