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Multi-Organoid System Provides Novel Platform for T2DM Research
A multi-organoid system developed from human induced pluripotent stem cells can simulate human liver-islet axis in type 2 diabetes, providing a novel platform for type 2 diabetes research.
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How To Land Therapeutic Genes Safely in the Human Genome
Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called “genomic safe harbors (GSHs).”
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Two Proteins Identified As Influencing the Aging Process
Research suggests that two proteins, apolipoprotein(a) and vascular cell adhesion molecule 1, influence how long and healthy a life we live.
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Peptide-Enhanced Anticancer Drug Targets Bone Metastasis
An affinity peptide for the bone cancer niche has been attached to a breast cancer drug, and the combined therapy has shown promise for cancer treatment in rodent models.
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Experimental Drug for Rare Type of ALS Begins Clinical Testing
An experimental drug called ION363 is being investigated in ALS patients in a global, Phase 3 clinical trial taking place in the United States, Europe and Asia.
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Broccoli Compound Could Be Exploited To Treat Cancer
A molecule found once broccoli is digested has been shown to trigger apoptosis in exponentially dividing cells, suggesting it could be used as a potential cancer treatment.
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Melanoma Primes Lymph Nodes for Tumor Spread
According to a new study, melanoma cells release small extracellular packages containing the protein nerve growth factor receptor, which primes nearby lymph nodes for tumor metastases.
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Investigating Interactions Between Anticancer Drug Olaparib and the Single Cell
Research has revealed the mechanism of action of the anticancer drug olaparib, used to treat triple-negative breast cancer.
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Disease-Modifying Antirheumatic Drugs Don’t Appear To Protect Rheumatoid Arthritis Patients Against Parkinson’s
A study has found that disease-modifying antirheumatic drugs were not associated with lower risk of Parkinson’s disease in individuals with rheumatoid arthritis.
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Naturally Occurring Vesicles in the Blood of COVID-19 Patients Show Therapeutic Potential
Scientists have identified natural extracellular vesicles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients that can block infection from broad strains of SARS-CoV-2 virus in preclinical studies.
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