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Mechanism Behind Ketamine’s Rapid Antidepressant Action Revealed
Researchers have discovered that ketamine’s rapid antidepressant action is due to specific synaptic effects. This represents a new target when developing drugs to treat depression.
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Retinoid Therapy Improves Vision in Mice With Usher Syndrome
Researchers have documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss.
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Turning Genes “On” and “Off” With New Epigenetic Editing Technique
Type 1 diabetes, rheumatoid arthritis and cancer are just some of the disorders associated with specific genes not “turning on” and “turning off” as they should. Using new CRISPR/Cas9 genome editing technology, researchers have described a new technique that can potentially be used to explore novel ways of treating diseases associated with dysregulation in DNA methylation.
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Drug Used To Prevent Miscarriage May Increase Offspring’s Risk of Developing Cancer
Scientists looking for drugs to improve the survival of children with high-risk neuroblastoma found a promising candidate in CX-5461 but also discovered that life-threatening side effects such as acute myeloid leukemia or cardiotoxicity can emerge years later.
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Intestinal Bacteria Use the Bloodstream as a Communication Highway With the Body
New understanding of how intestinal bacteria communicate with the body will help to improve understanding of the influence of intestinal bacteria on diseases and could support the development of innovative forms of drug or vaccine delivery.
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Fat-Secreted Molecule Diminishes Effects of Common Cancer Drug
Leptin, a molecule produced by fat cells, appears to diminish the effects of tamoxifen, an estrogen-blocking therapy used to treat and prevent breast cancers.
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Study Raises Safety Concerns for Neuroblastoma Drug Candidate
A team from St. Jude Children’s Research Hospital has discovered the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.
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The Placebo Effect (and Dopamine) Can Affect Antidepressants' Efficacy
Levels of dopamine and the placebo effect can determine whether patients with social anxieties improve when treated with SSRIs. A new study shows the effect was four times higher for patients with high expectations of the medication compared with patients with low expectations.
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Intestine Chip Created To Test Potential Treatments for COVID-19
Scientists used a human Intestine Chip to study coronavirus infection and potential treatments in an environment that mimics the human intestine more effectively than cells grown in a dish.
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Alzheimer’s Trial Will Test Two Drugs in Combination
The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) at Washington University School of Medicine in St. Louis has announced that it will be targeting two key Alzheimer’s proteins – amyloid and tau – as part of its Tau Next Generation Alzheimer’s prevention trial.
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