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Researchers have created a compound that can reverse pain by regulating NaV1.7, a sodium ion channel linked to the sensation of pain. The compound was tested using nerve cells from four different species as well as animal models.

Researchers have identified an important molecular mechanism that could help to develop a novel treatment for drug-resistant seizures in newborns.

According to research, bacteria found in children’s upper respiratory systems could help fight chronic middle ear infections.

Researchers have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects.

A clinical trial is being launched for auceliciclib, a world-first drug that may provide the breakthrough for 500,000 people currently battling pancreatic cancer.

Researchers have discovered that ketamine’s rapid antidepressant action is due to specific synaptic effects. This represents a new target when developing drugs to treat depression.

Researchers have documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss.

Type 1 diabetes, rheumatoid arthritis and cancer are just some of the disorders associated with specific genes not “turning on” and “turning off” as they should. Using new CRISPR/Cas9 genome editing technology, researchers have described a new technique that can potentially be used to explore novel ways of treating diseases associated with dysregulation in DNA methylation.

Scientists looking for drugs to improve the survival of children with high-risk neuroblastoma found a promising candidate in CX-5461 but also discovered that life-threatening side effects such as acute myeloid leukemia or cardiotoxicity can emerge years later.

New understanding of how intestinal bacteria communicate with the body will help to improve understanding of the influence of intestinal bacteria on diseases and could support the development of innovative forms of drug or vaccine delivery.