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New Drug-Like Molecule Counteracts Epigenetic Drivers of Cancer
In a new study published in Cell Chemical Biology, researchers report the development of a drug-like molecule that can counteract the effects of mutated epigenetic regulators, which are known to drive various cancers.
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Switch Selectively Turns On RNA Therapies
Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene.
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Monoclonal Antibody Shows Promise for Severe Asthma in Phase 2 Trial
A new monoclonal antibody therapy called itepekimab shows promise as an alternative treatment for patients with moderate-to-severe asthma. Itepekimab was shown to be safe and effective in a Phase 2 trial, results were published in the journal New England Journal of Medicine.
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Identifying Drivers of Treatment Resistance in Metastatic Breast Cancer
Researchers have discovered a genetic signature that can identify drivers of poor outcomes in advanced estrogen-receptor positive (ER+) breast cancer, which could lead to personalized treatment for patients.
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Therapy for Mesothelioma and Metastatic Cancer Enters Phase 1 Trial
A new therapy for mesothelioma and metastatic cancer, discovered from work conducted at the University of Vermont, is about to enter a Phase I clinical trial.
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Ribosome-Targeting Antibiotic Designed To Fight Drug-Resistant Bacteria
A study reports on a novel antibiotic that binds to the ribosome of bacterial cells and stops drug-resistant pathogens from making mice sick.
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Mathematical Model Optimizes Vaccine Development
Researchers have used a mathematical model to better understand the immune response to vaccines, which could help improve vaccine design and simplify the associated technical challenges.
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Light “Tweezers” Could Aid Vaccine Development
A team of scientists led by Nanyang Technological University, Singapore (NTU Singapore) has created a laser-powered device that can trap and move viruses using light.
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Computer Modeling Tool Designed To Improve Drug Targeting, Efficacy and Safety
A computer modeling method has been designed to predict novel sites of drug binding and can help to achieve more effective drug targeting, improving efficacy and safety.
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Four Existing Drugs Reverse Alzheimer's in Mice
A study has managed to reverse the symptoms of Alzheimer's disease in mice by administering drugs currently used to treat hypertension and inflammation in humans.
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