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A new study conducted using mice suggests that targeting the alpha-synuclein protein may not be sufficient to treat the disease and alleviate symptoms in most patients.

Researchers are hopeful that new understanding of cellular defects related to cystic fibrosis could help pave the way for treatment of the disease.

The investigational Alzheimer’s drug CMS121 has now moved into a Phase I clinical trial to evaluate its safety in humans. In preclinical studies with mice, CMS121 was shown to reverse signs of aging in the brain and could prevent memory loss associated with Alzheimer’s disease.

Researchers have found that a drug first developed to treat Alzheimer’s disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function without changes in food intake or daily activity.

Researchers have identified a small molecule that could, in the future, be administered alongside standard chemotherapy to prevent the spread of colorectal cancer.

How is two meters of DNA packed into the tiny nucleus of a cell? Scientists have uncovered the molecular processes by which a complex of proteins act as the "Marie Kondo" of molecular biology, folding DNA into neat loops.

In order to study the effect of reduced exercise on metabolism and diet composition, researchers simulated in mice a sharp decline in physical activity by removing a voluntary running wheel, and assessed how diet composition affects the response.

The gene TNK1 is present in all cells, but when mutated, it becomes dangerous and able to convert normal cells into cancer cells. Researchers have discovered the mechanism by which TNK1 becomes an oncogenic driver in cancer.

Researchers have developed a new way to determine whether individual patients will respond to a specific cancer drug or not. This kind of test could help doctors to choose alternative therapies for patients who don’t respond to the therapies normally used to treat their cancer.

The World Health Organization (WHO) is recommending widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine among children in sub-Saharan Africa and in other regions with moderate to high P. falciparum malaria transmission.